Research workbench

NEDD4 hect A889F structure

Analyse NEDD4 hect A889F structure in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4BE8
Type: protein
Length: 378 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: E3 ubiquitin-protein ligase NEDD4
EC: 6.3.2.-
UniProt: P46934
Pockets: 5 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 47% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	E3 ubiquitin-protein ligase NEDD4 (EC 6.3.2.-)	protein	378	47% helix, 11% strand	P46934

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	359	0.63	0.79	36	empty
2	73	0.50	0.84	14	empty
3	59	0.47	0.84	12	empty
4	77	0.34	0.75	21	empty
5	52	0.27	0.74	13	empty

Compared structures

4BE8 · NEDD4 HECT A889F structure · the same entry in another collection · chain A against A, TM-score 1.00
P46934 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46934) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46934
Elsewhere: RCSB PDB 4BE8 · PDBe 4BE8 · UniProt P46934

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.