UniProt P46934
E3 ubiquitin-protein ligase NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (UniProt P46934): 25 experimental structures and 1 predicted model on GenesisL1, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P46934
- Protein
- E3 ubiquitin-protein ligase NEDD4
- Experimental structures
- 25
- Predicted models
- 1
- Pockets
- 7 · 1 record with a druggable one
Structures
26 records of P46934 in the MolNFT archive: 25 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2KPZ | Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein… | solution nmr | A | — | — |
| 2KPZ | Human NEDD4 3RD ww domain complex with the human T-cell leukemia virus 1 gag-pro poliprotein… | solution nmr | A | — | — |
| 2KQ0 | Human NEDD4 3rd WW Domain Complex with Ebola Zaire Virus Matrix Protein VP40 Derived Peptide… | solution nmr | A | — | — |
| 2KQ0 | Human NEDD4 3RD ww domain complex with ebola zaire virus matrix protein VP40 derived peptide… | solution nmr | A | — | — |
| 2M3O | Structure and dynamics of a human Nedd4 WW domain-ENaC complex | solution nmr | W | — | — |
| 2M3O | Structure and dynamics of a human NEDD4 ww domain-ENAC complex | solution nmr | W | — | — |
| 2XBB | Nedd4 HECT:Ub complex | x-ray diffraction | A, B | — | — |
| 2XBB | NEDD4 HECT:UB complex | x-ray diffraction | A, B | — | — |
| 2XBF | Nedd4 HECT structure | x-ray diffraction | A | — | — |
| 2XBF | NEDD4 hect structure | x-ray diffraction | A | — | — |
| 3B7Y | Crystal structure of the C2 Domain of the E3 Ubiquitin-Protein Ligase NEDD4 | x-ray diffraction | A, B | — | — |
| 3B7Y | Crystal structure of the C2 domain of the E3 ubiquitin- protein ligase NEDD4 | x-ray diffraction | A, B | — | — |
| 4BBN | NEDD4 HECT-Ub:Ub complex | x-ray diffraction | A | — | — |
| 4BBN | NEDD4 hect-UB:UB complex | x-ray diffraction | A | — | — |
| 4BE8 | NEDD4 HECT A889F structure | x-ray diffraction | A | — | — |
| 4BE8 | NEDD4 hect A889F structure | x-ray diffraction | A | — | — |
| 4N7F | Crystal structure of 3rd WW domain of human Nedd4-1 | x-ray diffraction | A, B | — | — |
| 4N7F | Crystal structure of 3RD ww domain of human NEDD4-1 | x-ray diffraction | A, B | — | — |
| 4N7H | Crystal Structure of the Complex of 3rd WW domain of Human Nedd4 and 1st PPXY Motif of ARRDC3 | x-ray diffraction | A | — | — |
| 4N7H | Crystal structure of the complex of 3RD ww domain of human NEDD4 and 1ST ppxy motif of ARRDC3 | x-ray diffraction | A | — | — |
| 5AHT | Third WW domain from the E3 ubiquitin-protein ligase NEDD4 | solution nmr | A | — | — |
| 5AHT | Third ww domain from the E3 ubiquitin-protein ligase NEDD4 | solution nmr | A | — | — |
| 5C7J | Crystal structure of NEDD4 with a ub variant | x-ray diffraction | A, B | — | — |
| 5C91 | NEDD4 HECT with covalently bound indole-based inhibitor | x-ray diffraction | A | — | — |
| 5C91 | NEDD4 hect with covalently bound indole-based inhibitor | x-ray diffraction | A | — | — |
| P46934 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46934) | predicted | A | — | 7 (best 0.76) |
Experiment against prediction
- 4N7H chain A against the predicted model P46934: TM-score 0.92, RMSD 0.45 Å
- 4N7H chain A against the predicted model P46934: TM-score 0.92, RMSD 0.45 Å
- 4N7F chain A against the predicted model P46934: TM-score 0.79, RMSD 1.49 Å
- 4N7F chain A against the predicted model P46934: TM-score 0.79, RMSD 1.49 Å
- 2XBB chain A against the predicted model P46934: TM-score 0.76, RMSD 3.50 Å
- 2XBB chain A against the predicted model P46934: TM-score 0.76, RMSD 3.50 Å
- 5C7J chain B against the predicted model P46934: TM-score 0.74, RMSD 3.88 Å
- 5C7J chain A against the predicted model P46934: TM-score 0.74, RMSD 3.94 Å
- 4BBN chain A against the predicted model P46934: TM-score 0.74, RMSD 3.92 Å
- 4BBN chain A against the predicted model P46934: TM-score 0.74, RMSD 3.92 Å
Elsewhere
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