MolNFT v1 · #262923 · protein
AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46934)
P46934: “AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase NEDD4 (P46934)”. 7 pockets (best druggability 0.76). MolNFT v1 #262923 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P46934
- Type
- protein
- Length
- 1,319 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x5c4adF1416281C09AE8eE1cbb80fF7e44cE86F97
- Molecule
- E3 ubiquitin-protein ligase NEDD4
- UniProt
- P46934
- Pockets
- 7 · best druggability 0.76
Structure
1 distinct chain · 16% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | E3 ubiquitin-protein ligase NEDD4 | protein | 1319 | 16% helix, 9% strand | P46934 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1097 | 0.76 | 0.78 | 77 | empty |
| 2 | 1144 | 0.73 | 0.76 | 82 | empty |
| 3 | 342 | 0.61 | 0.77 | 34 | empty |
| 4 | 90 | 0.39 | 0.77 | 20 | empty |
| 5 | 73 | 0.33 | 0.75 | 18 | empty |
Compared structures
- 4BBN · NEDD4 hect-UB:UB complex · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 4BBN · NEDD4 HECT-Ub:Ub complex · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 2XBB · Nedd4 HECT:Ub complex · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 2XBB · NEDD4 HECT:UB complex · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 5C7J · Crystal structure of NEDD4 with a ub variant · an experimental structure of the same protein · chain A against A, TM-score 0.23
- 5C91 · NEDD4 HECT with covalently bound indole-based inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 5C91 · NEDD4 hect with covalently bound indole-based inhibitor · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 2XBF · Nedd4 HECT structure · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 2XBF · NEDD4 hect structure · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 4BE8 · NEDD4 hect A889F structure · an experimental structure of the same protein · chain A against A, TM-score 0.21
- 4BE8 · NEDD4 HECT A889F structure · an experimental structure of the same protein · chain A against A, TM-score 0.21
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46934
- Elsewhere: UniProt P46934 · AlphaFold DB P46934
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