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Crystal structure of subtype-switched epithelial adhesin 1 to 2 a domain (EPA1TO2A) from candida glabrata in complex with glycerol

Analyse Crystal structure of subtype-switched epithelial adhesin 1 to 2 a domain… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 4AFA
Type: protein
Length: 227 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: EPA1P
UniProt: Q6VBJ0
Ligands: GLC, GAL, CA
Pockets: 1 · best druggability 0.36

Structure

x-ray diffraction · 1 distinct chain · 7% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	EPA1P	protein	227	7% helix, 41% strand	Q6VBJ0

Ligands and binding sites

GLC · alpha-D-glucopyranose · sugar · chains A
GAL · beta-D-galactopyranose · sugar · chains A
CA · Calcium ion · metal · chains A
GOL · Glycerol · additive · 3 copies · chains A
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	79	0.36	0.76	24	empty

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

4AFA · Crystal Structure of subtype-switched Epithelial Adhesin 1 to 2 A domain (Epa1to2A) from… · the same entry in another collection · chain A against A, TM-score 1.00

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Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q6VBJ0
Elsewhere: RCSB PDB 4AFA · PDBe 4AFA · UniProt Q6VBJ0

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