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Crystal structure of 26S proteasome subunit RPN2
Analyse Crystal structure of 26S proteasome subunit RPN2 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4ADY
- Type
- protein
- Length
- 1,651 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 26S proteasome regulatory subunit RPN2
- UniProt
- P32565
- Pockets
- 10 · best druggability 0.85
Structure
x-ray diffraction · 2 distinct chains · 64% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit RPN2 | protein | 849 | 64% helix, 5% strand | P32565 |
| B | 26S proteasome regulatory subunit RPN2 | protein | 802 | 63% helix, 5% strand | P32565 |
Pockets
10 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1070 | 0.85 | 0.86 | 110 | empty |
| 2 | 1199 | 0.82 | 0.83 | 129 | empty |
| 3 | 468 | 0.68 | 0.79 | 35 | empty |
| 4 | 189 | 0.52 | 0.78 | 25 | empty |
| 5 | 105 | 0.51 | 0.82 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 907 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 40 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32565
- Elsewhere: RCSB PDB 4ADY · PDBe 4ADY · UniProt P32565
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