MolNFT v1 · #385811 · protein
AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN2 (P32565)
P32565: “AlphaFold monomer V2.0 prediction for 26S proteasome regulatory subunit RPN2 (P32565)”. 13 pockets (best druggability 0.85). MolNFT v1 #385811 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P32565
- Type
- protein
- Length
- 945 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xe1a85DF48870124Ac6330A08Fe9b4CEfa75DA51F
- Molecule
- 26S proteasome regulatory subunit RPN2
- UniProt
- P32565
- Pockets
- 13 · best druggability 0.85
Structure
1 distinct chain · 63% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 26S proteasome regulatory subunit RPN2 | protein | 945 | 63% helix, 4% strand | P32565 |
Pockets
13 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1002 | 0.85 | 0.86 | 114 | empty |
| 2 | 137 | 0.62 | 0.85 | 25 | empty |
| 3 | 147 | 0.61 | 0.85 | 27 | empty |
| 4 | 145 | 0.45 | 0.76 | 20 | empty |
| 5 | 79 | 0.44 | 0.80 | 16 | empty |
Compared structures
- 6FVW · 26S proteasome, s4 state · an experimental structure of the same protein · chain A against N, TM-score 0.88
- 4ADY · Crystal structure of 26S proteasome subunit Rpn2 · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 4ADY · Crystal structure of 26S proteasome subunit RPN2 · an experimental structure of the same protein · chain A against A, TM-score 0.87
- 5MPC · 26S proteasome in presence of BeFx (s4) · an experimental structure of the same protein · chain A against N, TM-score 0.85
- 6FVY · 26S proteasome, s6 state · an experimental structure of the same protein · chain A against N, TM-score 0.85
- 6FVX · 26S proteasome, s5 state · an experimental structure of the same protein · chain A against N, TM-score 0.85
- 6FVV · 26S proteasome, s3 state · an experimental structure of the same protein · chain A against N, TM-score 0.85
- 6FVU · 26S proteasome, s2 state · an experimental structure of the same protein · chain A against N, TM-score 0.85
- 5MPD · 26S proteasome in presence of ATP (s1) · an experimental structure of the same protein · chain A against N, TM-score 0.84
- 5MPD · 26S proteasome in presence of ATP (S1) · an experimental structure of the same protein · chain A against N, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32565
- Elsewhere: UniProt P32565 · AlphaFold DB P32565
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