X-ray crystal structure of human galectin-1

Structure

x-ray diffraction · 1 distinct chain · 0% helix, 60% strand (DSSP).

Ligands and binding sites

• BGC · beta-D-glucopyranose · sugar · 2 copies · chains A, B
• GAL · beta-D-galactopyranose · sugar · 2 copies · chains A, B
• SO4 · Sulfate ion · ion · chains A
• BME · Beta-mercaptoethanol · additive · 5 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 609 Ų buried · 17 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 covalent, 1 modified (additive adduct, oxidation).

Compared structures

• 1GZW · X-ray crystal structure of human galectin-1 · the same entry in another collection · chain A against A, TM-score 1.00
• P09382 · AlphaFold monomer V2.0 prediction for galectin-1 (P09382) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P09382
• Elsewhere: RCSB PDB 1GZW · PDBe 1GZW · UniProt P09382