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Staphylococcus aureus ftsz GDP-form

Analyse Staphylococcus aureus ftsz GDP-form in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3VO8
Type: protein
Length: 609 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cell division protein ftsz
UniProt: P0A029
Ligands: GDP, CA
Pockets: 7 · best druggability 0.59

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cell division protein ftsz	protein	305	45% helix, 23% strand	P0A029
B	Cell division protein ftsz	protein	304	45% helix, 24% strand	P0A029

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · 2 copies · chains A, B
CA · Calcium ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	419	0.59	0.75	51	empty
2	206	0.59	0.81	40	GDP
3	239	0.59	0.80	43	GDP
4	110	0.50	0.81	23	empty
5	110	0.46	0.79	19	empty

Interfaces

1 interface between chains.

A–B · 89 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

3VO8 · Staphylococcus aureus FtsZ GDP-form · the same entry in another collection · chain A against A, TM-score 1.00
P0A029 · AlphaFold monomer V2.0 prediction for cell division protein ftsz (P0A029) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A029
Elsewhere: RCSB PDB 3VO8 · PDBe 3VO8 · UniProt P0A029

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