Research workbench
Murine apoptosis-inducing factor (aif)
Analyse Murine apoptosis-inducing factor (aif) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1GV4
- Type
- protein
- Length
- 980 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Programed cell death protein 8
- UniProt
- Q9Z0X1
- Ligands
- FAD
- Pockets
- 9 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Programed cell death protein 8 | protein | 490 | 28% helix, 29% strand | Q9Z0X1 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1028 | 0.81 | 0.82 | 95 | FAD |
| 2 | 1033 | 0.81 | 0.82 | 93 | FAD |
| 3 | 88 | 0.43 | 0.79 | 24 | empty |
| 4 | 54 | 0.42 | 0.82 | 16 | empty |
| 5 | 95 | 0.41 | 0.78 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 869 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z0X1
- Elsewhere: RCSB PDB 1GV4 · PDBe 1GV4 · UniProt Q9Z0X1
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