UniProt Q9Z0X1
Apoptosis-inducing factor 1, mitochondrial (Q9Z0X1)
Apoptosis-inducing factor 1, mitochondrial (UniProt Q9Z0X1), EC 1.1.1.-, 1.6.99.-: 11 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 36 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9Z0X1
- Protein
- Apoptosis-inducing factor 1, mitochondrial
- EC
- 1.1.1.-, 1.6.99.-
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 36 · 3 records with a druggable one
Structures
12 records of Q9Z0X1 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GV4 | Murine apoptosis-inducing factor (AIF) | x-ray diffraction | A, B | FAD | 9 (best 0.81) |
| 1GV4 | Murine apoptosis-inducing factor (aif) | x-ray diffraction | A, B | — | — |
| 3GD3 | Crystal structure of a naturally folded murine apoptosis inducing factor | x-ray diffraction | A, B, C, D | — | — |
| 3GD3 | Crystal structure of a naturally folded murine apoptosis inducing factor | x-ray diffraction | A, B, C, D | — | — |
| 3GD4 | Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor | x-ray diffraction | A, B | — | — |
| 3GD4 | Crystal structure of the reduced, NAD-bound form of murine apoptosis inducing factor | x-ray diffraction | A, B | — | — |
| 5MIU | G307E variant of Murine Apoptosis Inducing Factor (oxidized state) | x-ray diffraction | A, B | FAD | — |
| 5MIU | G307E variant of murine apoptosis inducing factor (oxidized state) | x-ray diffraction | A, B | FAD | — |
| 5MIV | G307E variant of murine Apoptosis Inducing Factor in complex with NAD+ | x-ray diffraction | A, C | NAD, FAD | 9 (best 0.82) |
| 5MIV | G307E variant of murine apoptosis inducing factor in complex with NAD+ | x-ray diffraction | A, C | NAD, FAD | — |
| 8QNS | Crystal structure of murine AIF bound to N-terminal domain of CHCHD4 | x-ray diffraction | A, D, G, J | FAD, NAD | 18 (best 0.83) |
| Q9Z0X1 | AlphaFold monomer V2.0 prediction for apoptosis-inducing factor 1, mitochondrial (Q9Z0X1) | predicted | A | — | — |
Ligands
Experiment against prediction
- 3GD3 chain A against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.72 Å
- 3GD3 chain A against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.72 Å
- 5MIU chain A against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.72 Å
- 5MIU chain A against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.72 Å
- 3GD3 chain C against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.77 Å
- 3GD3 chain C against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.77 Å
- 3GD3 chain B against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.94 Å
- 3GD3 chain B against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.94 Å
- 3GD3 chain D against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.90 Å
- 3GD3 chain D against the predicted model Q9Z0X1: TM-score 0.99, RMSD 0.90 Å
Elsewhere
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