Research workbench
Structure of the shwanavidin-biotin complex
Analyse Structure of the shwanavidin-biotin complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SZJ
- Type
- protein
- Length
- 239 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- AVIDIN/STREPTAVIDIN
- UniProt
- Q12QS6
- Ligands
- BTN, CO3
- Pockets
- 2 · best druggability 0.61
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 62% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | AVIDIN/STREPTAVIDIN | protein | 120 | 3% helix, 61% strand | Q12QS6 |
| B | AVIDIN/STREPTAVIDIN | protein | 119 | 3% helix, 63% strand | Q12QS6 |
Ligands and binding sites
- BTN · Biotin · ligand · 2 copies · chains A, B
- CO3 · Carbonate ion · ion · chains A, B
- ACY · Acetic acid · additive · 2 copies · chains A, B
- GOL · Glycerol · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 87 | 0.61 | 0.88 | 18 | BTN |
| 2 | 92 | 0.58 | 0.86 | 18 | BTN |
Interfaces
1 interface between chains.
- A–B · 1735 Ų buried · 27 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 3SZJ · Structure of the shwanavidin-biotin complex · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12QS6
- Elsewhere: RCSB PDB 3SZJ · PDBe 3SZJ · UniProt Q12QS6
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