Research workbench
Crystal structure of mmachc (1-238), a human B12 processing enzyme, complexed with methylcobalamin
Analyse Crystal structure of mmachc (1-238), a human B12 processing enzyme, complexed… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3SC0
- Type
- protein
- Length
- 237 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methylmalonic aciduria and homocystinuria type C protein
- UniProt
- Q9Y4U1
- Ligands
- COB
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methylmalonic aciduria and homocystinuria type C protein | protein | 237 | 38% helix, 17% strand | Q9Y4U1 |
Ligands and binding sites
- COB · Co-methylcobalamin · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 462 | 0.62 | 0.76 | 34 | COB |
| 2 | 58 | 0.28 | 0.73 | 15 | empty |
Compared structures
- 3SC0 · Crystal Structure of MMACHC (1-238), a human B12 processing enzyme, complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y4U1 · AlphaFold monomer V2.0 prediction for cyanocobalamin reductase / alkylcobalamin… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y4U1
- Elsewhere: RCSB PDB 3SC0 · PDBe 3SC0 · UniProt Q9Y4U1
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