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Crystal structure of a AAR2-PRP8 complex

Analyse Crystal structure of a AAR2-PRP8 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3SBT
Type: protein
Length: 553 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pre-mRNA-splicing factor 8; A1 cistron-splicing factor AAR2
UniProt: P33334, P32357
Ligands: SO4
Pockets: 6 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pre-mRNA-splicing factor 8	protein	253	46% helix, 18% strand	P33334
B	A1 cistron-splicing factor AAR2	protein	300	44% helix, 20% strand	P32357

Ligands and binding sites

SO4 · Sulfate ion · ion · 2 copies · chains A, B
PGO · S-1,2-propanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1128	0.72	0.76	77	empty
2	170	0.48	0.76	34	empty
3	128	0.43	0.76	20	empty
4	74	0.37	0.78	17	empty
5	63	0.37	0.79	15	empty

Interfaces

1 interface between chains.

A–B · 823 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

3SBT · Crystal structure of a Aar2-Prp8 complex · the same entry in another collection · chain A against A, TM-score 1.00
P32357 · AlphaFold monomer V2.0 prediction for A1 cistron-splicing factor AAR2 (P32357) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P33334
Every structure of UniProt P32357
Elsewhere: RCSB PDB 3SBT · PDBe 3SBT · UniProt P33334 · UniProt P32357

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