UniProt P32357
A1 cistron-splicing factor AAR2 (P32357)
A1 cistron-splicing factor AAR2 (UniProt P32357): 291 experimental structures and 1 predicted model on GenesisL1, 67 ligands bound, 466 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P32357
- Protein
- A1 cistron-splicing factor AAR2
- Experimental structures
- 291
- Predicted models
- 1
- Ligands
- 67
- Pockets
- 466 · 1 record with a druggable one
Structures
292 records of P32357 in the MolNFT archive: 291 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3SBS | Crystal structure of Aar2 protein | x-ray diffraction | A | — | — |
| 3SBS | Crystal structure of AAR2 protein | x-ray diffraction | A | — | — |
| 3SBT | Crystal structure of a Aar2-Prp8 complex | x-ray diffraction | B | — | — |
| 3SBT | Crystal structure of a AAR2-PRP8 complex | x-ray diffraction | B | — | — |
| 3ZEF | Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution | x-ray diffraction | A, D | — | — |
| 3ZEF | Crystal structure of PRP8:AAR2 complex: second crystal form at 3.1 ångström resolution | x-ray diffraction | A, D | — | — |
| 4I43 | Crystal structure of Prp8:Aar2 complex | x-ray diffraction | A | — | — |
| 4I43 | Crystal structure of PRP8:AAR2 complex | x-ray diffraction | A | — | — |
| 4ILG | Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains | x-ray diffraction | A | — | — |
| 4ILG | Crystal structure of AAR2P in complex with the PRP8P rnaseh and JAB1/MPN domains | x-ray diffraction | A | — | — |
| 4ILH | Crystal structure of an Aar2p C-terminal deletion mutant in conplex with Prp8p RNaseH | x-ray diffraction | B | — | — |
| 4ILH | Crystal structure of an AAR2P C-terminal deletion mutant in conplex with PRP8P rnaseh | x-ray diffraction | B | — | — |
| 4ILI | Crystal structure of an Aar2p S253E phosphomimetic mutant protein | x-ray diffraction | A, B | — | — |
| 4ILI | Crystal structure of an AAR2P S253E phosphomimetic mutant protein | x-ray diffraction | A, B | — | — |
| 5QY1 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry A07A | x-ray diffraction | B | R8A, SO4 | — |
| 5QY2 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry A12B | x-ray diffraction | B | TJ1 | — |
| 5QY3 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry B03A | x-ray diffraction | B | SYG | — |
| 5QY4 | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry B08a | x-ray diffraction | B | T9S, SO4 | 5 (best 0.43) |
| 5QY4 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry B08A | x-ray diffraction | B | T9S, SO4 | — |
| 5QY5 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C02A | x-ray diffraction | B | SYA | — |
| 5QY6 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C05A | x-ray diffraction | B | — | — |
| 5QY7 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C08A | x-ray diffraction | B | USJ | — |
| 5QY8 | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry C10a | x-ray diffraction | B | SO4 | — |
| 5QY8 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C10A | x-ray diffraction | B | SO4 | — |
| 5QY9 | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry C11b | x-ray diffraction | B | — | — |
| 5QY9 | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry C11B | x-ray diffraction | B | — | — |
| 5QYA | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry D02A | x-ray diffraction | B | SY4, SO4 | — |
| 5QYB | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry D06a | x-ray diffraction | B | — | 7 (best 0.43) |
| 5QYB | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry D06A | x-ray diffraction | B | — | — |
| 5QYC | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry D07A | x-ray diffraction | B | SO4 | — |
| 5QYD | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry E05A | x-ray diffraction | B | — | — |
| 5QYE | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry E12A | x-ray diffraction | B | SO4 | — |
| 5QYF | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry F02A | x-ray diffraction | B | T9Y | — |
| 5QYG | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry F08a | x-ray diffraction | B | SO4, RBJ | — |
| 5QYG | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry F08A | x-ray diffraction | B | SO4, RBJ | — |
| 5QYH | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry G04A | x-ray diffraction | B | SO4 | — |
| 5QYI | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry G12a | x-ray diffraction | B | SZ7 | 4 (best 0.42) |
| 5QYI | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry G12A | x-ray diffraction | B | SZ7 | — |
| 5QYJ | PanDDA analysis group deposition -- Aar2/RNaseH in complex with fragment F2X-Entry H11a | x-ray diffraction | B | — | 5 (best 0.40) |
| 5QYJ | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry H11A | x-ray diffraction | B | — | — |
| 5QYK | Pandda analysis group deposition -- AAR2/RNASEH in complex with fragment F2X-entry H12A | x-ray diffraction | B | SZA, SO4 | — |
| 5QYL | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 01 | x-ray diffraction | B | — | — |
| 5QYL | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 01 | x-ray diffraction | B | — | — |
| 5QYM | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 02 | x-ray diffraction | B | — | — |
| 5QYN | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 03 | x-ray diffraction | B | — | — |
| 5QYO | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 04 | x-ray diffraction | B | — | — |
| 5QYO | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 04 | x-ray diffraction | B | — | — |
| 5QYP | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 05 | x-ray diffraction | B | — | — |
| 5QYQ | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 06 | x-ray diffraction | B | — | — |
| 5QYR | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 07 | x-ray diffraction | B | — | — |
| 5QYR | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 07 | x-ray diffraction | B | — | — |
| 5QYS | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 08 | x-ray diffraction | B | — | 5 (best 0.41) |
| 5QYS | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 08 | x-ray diffraction | B | — | — |
| 5QYT | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 09 | x-ray diffraction | B | — | — |
| 5QYT | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 09 | x-ray diffraction | B | — | — |
| 5QYU | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 10 | x-ray diffraction | B | — | — |
| 5QYV | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 11 | x-ray diffraction | B | — | — |
| 5QYW | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 12 | x-ray diffraction | B | — | 6 (best 0.42) |
| 5QYW | Pandda analysis group deposition -- auto-refined data of AAR2/RNASEH for ground state model 12 | x-ray diffraction | B | — | — |
| 5QYX | PanDDA analysis group deposition -- Auto-refined data of Aar2/RNaseH for ground state model 13 | x-ray diffraction | B | — | 5 (best 0.42) |
232 records more on the page itself.
Ligands
- SO4 · Sulfate ion · in 12 records
- RBJ · 4-[(methylamino)methyl]phenol · in 3 records
- SZ7 · ~{N}-[(~{E})-thiophen-2-ylmethylideneamino]cyclopropanecarboxamide · in 3 records
- R8A · (2-aminopyridin-3-yl)methanol · in 2 records
- R8V · (3S)-3-hydroxy-2-methyl-2,3-dihydro-1H-isoindol-1-one · in 2 records
- SY4 · ~{N}-[5-azanyl-2,4-bis(fluoranyl)phenyl]propane-1-sulfonamide · in 2 records
- SYA · 2,4,5-tris(fluoranyl)-3-methoxy-benzoic acid · in 2 records
- SYG · 2-[(1~{S})-1-azanylpropyl]phenol · in 2 records
- SZA · ~{N}-(2-thiophen-2-ylethyl)pyridine-4-carboxamide · in 2 records
- T9S · ethyl 1,3-dihydro-2H-pyrrolo[3,4-c]pyridine-2-carboxylate · in 2 records
- VHO · N-cyclopropyl-2-(3-fluorophenoxy)acetamide · in 2 records
- T9Y · Ethyl 5-(trifluoromethyl)-1H-pyrazole-4-carboxylate · in 1 record
- TJ1 · 3-(propan-2-yl)-1,2,4-oxadiazol-5(4H)-one · in 1 record
- USJ · (1S,3S)-2-methyl-2,3-dihydro-1H-isoindole-1,3-diol · in 1 record
- UZ8 · [2-(methylsulfanyl)pyridin-3-yl](pyrrolidin-1-yl)methanone · in 1 record
- V29 · (3R)-3-(benzylamino)oxolane-3-carboxylic acid · in 1 record
- V5I · 2-methyl-1-(2-methylphenyl)propan-2-amine · in 1 record
- V6I · N-(2-fluorophenyl)methanesulfonamide · in 1 record
- V6Z · methyl N-(2-chlorobenzoyl)glycinate · in 1 record
- V7C · N-[(2R)-2-cyanopropyl]benzamide · in 1 record
- V92 · 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonitrile · in 1 record
- VBI · N~2~-(3-chlorophenyl)-N~2~-(methanesulfonyl)-N-methylglycinamide · in 1 record
- VBX · N-methyl-2-{[2-(methylamino)-2-oxoethyl]amino}benzamide · in 1 record
- VCX · methyl 4-bromo-5-methyl-1H-pyrazole-3-carboxylate · in 1 record
- VE0 · N-hydroxy-2-(piperidin-1-yl)pyridine-3-carboximidamide · in 1 record
- VEX · (2,3,4-trimethoxyphenyl)methanol · in 1 record
- VI5 · N-(3-fluorophenyl)-N~2~-methylglycinamide · in 1 record
- VJ0 · (1S)-1-(3-fluoro-4-methoxyphenyl)ethan-1-amine · in 1 record
- VL8 · (2R)-2-(3,4-dichlorophenoxy)-N-methylbutanamide · in 1 record
- VNX · 5-cyclopropyl-2H-tetrazole · in 1 record
Experiment against prediction
- 5QZO chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5QYR chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5QYR chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5R0A chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5QZP chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5QZ5 chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5QZ5 chain B against the predicted model P32357: TM-score 1.00, RMSD 0.25 Å
- 5QZI chain B against the predicted model P32357: TM-score 1.00, RMSD 0.26 Å
- 5R0H chain B against the predicted model P32357: TM-score 1.00, RMSD 0.26 Å
- 5R0H chain B against the predicted model P32357: TM-score 1.00, RMSD 0.26 Å
Elsewhere
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