Research workbench
Crystal structure of HDLG1-PDZ1 complexed with apc
Analyse Crystal structure of HDLG1-PDZ1 complexed with apc in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3RL7
- Type
- protein
- Length
- 563 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disks large homolog 1; 11-mer peptide from adenomatous polyposis COLI protein
- UniProt
- Q12959, P25054
- Pockets
- 7 · best druggability 0.73
Structure
x-ray diffraction · 11 distinct chains · 16% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Disks large homolog 1 | protein | 89 | 17% helix, 38% strand | Q12959 |
| A | Disks large homolog 1 | protein | 90 | 16% helix, 36% strand | Q12959 |
| C | Disks large homolog 1 | protein | 87 | 16% helix, 40% strand | Q12959 |
| D | Disks large homolog 1 | protein | 92 | 16% helix, 37% strand | Q12959 |
| E | Disks large homolog 1 | protein | 82 | 18% helix, 43% strand | Q12959 |
| F | Disks large homolog 1 | protein | 91 | 16% helix, 36% strand | Q12959 |
| G | 11-mer peptide from adenomatous polyposis COLI protein | protein | 7 | 0% helix, 43% strand | P25054 |
| H, I | 11-mer peptide from adenomatous polyposis COLI protein | protein | 5 | 0% helix, 40% strand | P25054 |
| J | 11-mer peptide from adenomatous polyposis COLI protein | protein | 6 | 0% helix, 33% strand | P25054 |
| K | 11-mer peptide from adenomatous polyposis COLI protein | protein | 5 | 0% helix, 40% strand | P25054 |
| L | 11-mer peptide from adenomatous polyposis COLI protein | protein | 4 | 0% helix, 25% strand | P25054 |
Pockets
7 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 159 | 0.73 | 0.91 | 32 | empty |
| 2 | 96 | 0.67 | 0.92 | 31 | empty |
| 3 | 137 | 0.65 | 0.87 | 19 | empty |
| 4 | 57 | 0.46 | 0.84 | 15 | empty |
| 5 | 52 | 0.37 | 0.79 | 14 | empty |
Interfaces
17 interfaces between chains.
- A–G · 457 Ų buried · 12 hydrogen bonds · protein-protein
- B–A · 447 Ų buried · 5 hydrogen bonds · protein-protein
- A–F · 431 Ų buried · 5 hydrogen bonds · protein-protein
- B–D · 406 Ų buried · 4 hydrogen bonds · protein-protein
- C–J · 392 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 3RL7 · Crystal structure of hDLG1-PDZ1 complexed with APC · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12959
- Every structure of UniProt P25054
- Elsewhere: RCSB PDB 3RL7 · PDBe 3RL7 · UniProt Q12959 · UniProt P25054
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