UniProt P25054
Adenomatous polyposis coli protein (P25054)
Adenomatous polyposis coli protein (UniProt P25054): 53 experimental structures on GenesisL1, 7 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P25054
- Protein
- Adenomatous polyposis coli protein
- Experimental structures
- 53
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 11 · 2 records with a druggable one
Structures
53 records of P25054 in the MolNFT archive: 53 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DEB | Crystal structure of the N-terminal coiled coil domain from apc | x-ray diffraction | A, B | SO4 | — |
| 1DEB | Crystal structure of the N-terminal coiled coil domain from apc | x-ray diffraction | A, B | — | — |
| 1EMU | Structure of the axin rgs-homologous domain in complex with a samp repeat from apc | x-ray diffraction | B | — | — |
| 1EMU | Structure of the axin rgs-homologous domain in complex with a samp repeat from apc | x-ray diffraction | B | — | — |
| 1JPP | The Structure of a beta-Catenin Binding Repeat from Adenomatous Polyposis Coli (APC) in Complex… | x-ray diffraction | C, D | — | 3 (best 0.59) |
| 1JPP | The structure of a beta-catenin binding repeat from adenomatous polyposis COLI (apc) in complex… | x-ray diffraction | C, D | — | — |
| 1M5I | Crystal Structure of the coiled coil region 129-250 of the tumor suppressor gene product APC | x-ray diffraction | A | — | — |
| 1M5I | Crystal structure of the coiled coil region 129-250 of the tumor suppressor gene product apc | x-ray diffraction | A | — | — |
| 1T08 | Crystal structure of beta-catenin/ICAT helical domain/unphosphorylated APC R3 | x-ray diffraction | C | — | — |
| 1T08 | Crystal structure of beta-CATENIN/ICAT helical DOMAIN/UNPHOSPHORYLATED apc R3 | x-ray diffraction | C | — | — |
| 1TH1 | Beta-catenin in complex with a phosphorylated APC 20aa repeat fragment | x-ray diffraction | C, D | — | — |
| 1TH1 | Beta-catenin in complex with a phosphorylated apc 20AA repeat fragment | x-ray diffraction | C, D | — | — |
| 1V18 | The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated APC 20mer… | x-ray diffraction | B | — | — |
| 1V18 | The crystal structure of beta-catenin armadillo repeat complexed with a phosphorylated apc 20MER… | x-ray diffraction | B | — | — |
| 2RQU | Solution structure of the complex between the DDEF1 SH3 domain and the APC SAMP1 motif | solution nmr | B | — | — |
| 2RQU | Solution structure of the complex between the DDEF1 SH3 domain and the apc SAMP1 motif | solution nmr | B | — | — |
| 3AU3 | Crystal structure of armadillo repeat domain of APC | x-ray diffraction | A | — | — |
| 3AU3 | Crystal structure of armadillo repeat domain of apc | x-ray diffraction | A | — | — |
| 3QHE | Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis coli… | x-ray diffraction | A, C | — | — |
| 3QHE | Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis COLI… | x-ray diffraction | A, C | — | — |
| 3RL7 | Crystal structure of hDLG1-PDZ1 complexed with APC | x-ray diffraction | G, H, I, J, K, L | — | — |
| 3RL7 | Crystal structure of HDLG1-PDZ1 complexed with apc | x-ray diffraction | G, H, I, J, K, L | — | — |
| 3RL8 | Crystal structure of hDLG1-PDZ2 complexed with APC | x-ray diffraction | F | — | — |
| 3RL8 | Crystal structure of HDLG1-PDZ2 complexed with apc | x-ray diffraction | F | — | — |
| 3T7U | A NeW Crystal structure of APC-ARM | x-ray diffraction | A, B | — | — |
| 3T7U | A new crystal structure of apc-arm | x-ray diffraction | A, B | — | — |
| 4G69 | Structure of the Human Discs Large 1 PDZ2 - Adenomatous Polyposis Coli Cytoskeletal Polarity Complex | x-ray diffraction | B | — | — |
| 4G69 | Structure of the human discs large 1 PDZ2 - adenomatous polyposis COLI cytoskeletal polarity complex | x-ray diffraction | B | — | — |
| 4YJE | Crystal structure of APC-ARM in complexed with Amer1-A1 | x-ray diffraction | A | — | — |
| 4YJE | Crystal structure of apc-arm in complexed with AMER1-A1 | x-ray diffraction | A | — | — |
| 4YJL | Crystal structure of APC-ARM in complexed with Amer1-A2 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4YJL | Crystal structure of apc-arm in complexed with AMER1-A2 | x-ray diffraction | A, B, C, D, E, F | — | — |
| 4YK6 | Crystal structure of APC-ARM in complexed with Amer1-A4 | x-ray diffraction | A | — | — |
| 4YK6 | Crystal structure of apc-arm in complexed with AMER1-A4 | x-ray diffraction | A | — | — |
| 5B6G | Protein-protein interaction | x-ray diffraction | A | SO4 | — |
| 5B6G | Protein-protein interaction | x-ray diffraction | A | — | — |
| 5IZ6 | Protein-protein interaction | x-ray diffraction | A | SO4 | — |
| 5IZ6 | Protein-protein interaction | x-ray diffraction | A | — | — |
| 5IZ8 | Protein-protein interaction | x-ray diffraction | A, B | — | 4 (best 0.72) |
| 5IZ8 | Protein-protein interaction | x-ray diffraction | A, B | — | — |
| 5IZ9 | Protein-protein interaction | x-ray diffraction | A | — | 1 (best 0.43) |
| 5IZ9 | Protein-protein interaction | x-ray diffraction | A | — | — |
| 5IZA | Protein-protein interaction | x-ray diffraction | A | — | — |
| 5IZA | Protein-protein interaction | x-ray diffraction | A | — | — |
| 5Z8H | APC with an inhibitor | x-ray diffraction | A | — | — |
| 5Z8H | Apc with an inhibitor | x-ray diffraction | A | PHQ | — |
| 7F6M | Crystal structure of APC complexed with a peptide inhibitor MAI-516 | x-ray diffraction | A | SO4 | 1 (best 0.35) |
| 7F6M | Crystal structure of apc complexed with a peptide inhibitor mai-516 | x-ray diffraction | A | ANN, NH2, SO4 | — |
| 7F7O | APC-Asef FP assay tracer | x-ray diffraction | A | 4CI | 1 (best 0.26) |
| 7F7O | Apc-asef fp assay tracer | x-ray diffraction | A | PHQ, 4CI | — |
| 7XTY | Crystal Structure of the second PDZ domain from human PTPN13 in complex with APC peptide | x-ray diffraction | C, D | — | — |
| 8GSJ | APC-Asef tripeptide inhibitor | x-ray diffraction | A | K8C, GJZ, SO4 | 1 (best 0.30) |
| 8X2Q | The Crystal Structure of APC from Biortus. | x-ray diffraction | A | — | — |
Ligands
- SO4 · Sulfate ion · in 6 records
- 4CI · N-[3',6'-bis(oxidanyl)-3-oxidanylidene-spiro[2-benzofuran-1,9'-xanthene]-5-yl]methanethioamide · in 2 records
- PHQ · benzyl chlorocarbonate · in 2 records
- ANN · 4-methoxybenzoic acid · in 1 record
- GJZ · (1R,2S)-2-phenylcyclopropanamine · in 1 record
- K8C · 2-methylsulfanylpyrimidine-4-carbaldehyde · in 1 record
- NH2 · Amino group · in 1 record
Elsewhere
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