MolNFT v1 · #76332 · protein
Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis COLI and the tyrosine-rich domain of SAM68
3QHE · Adenomatous polyposis COLI protein: “Crystal structure of the complex between the armadillo repeat domain of adenomatous polyposis COLI and the…”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #76332 on GenesisL1…
- PDB
- 3QHE
- Type
- protein
- Length
- 662 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenomatous polyposis COLI protein; Kh domain-containing, RNA-binding, signal…
- UniProt
- P25054, Q07666
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenomatous polyposis COLI protein | protein | 323 | 76% helix, 0% strand | P25054 |
| B | Kh domain-containing, RNA-binding, signal transduction- associated protein 1 | protein | 10 | 0% helix, 0% strand | Q07666 |
| C | Adenomatous polyposis COLI protein | protein | 318 | 76% helix, 0% strand | P25054 |
| D | Kh domain-containing, RNA-binding, signal transduction- associated protein 1 | protein | 11 | 0% helix, 0% strand | Q07666 |
Pockets
3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 514 | 0.70 | 0.80 | 53 | empty |
| 2 | 255 | 0.60 | 0.80 | 36 | empty |
| 3 | 56 | 0.53 | 0.88 | 18 | empty |
Interfaces
4 interfaces between chains.
- C–D · 1037 Ų buried · 25 hydrogen bonds · protein-protein
- A–B · 914 Ų buried · 20 hydrogen bonds · protein-protein
- A–C · 488 Ų buried · 0 hydrogen bonds · protein-protein
- A–D · 206 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3QHE · Crystal structure of the complex between the armadillo repeat domain of adenomatous… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07666 · AlphaFold monomer V2.0 prediction for kh domain-containing, RNA- binding, signal… · a predicted model of the same protein · chain D against A, TM-score 0.39
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25054
- Every structure of UniProt Q07666
- Elsewhere: RCSB PDB 3QHE · PDBe 3QHE · UniProt P25054 · UniProt Q07666
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