MolNFT v1 · #141467 · protein
Apc with an inhibitor
5Z8H · Adenomatous polyposis COLI protein: “Apc with an inhibitor”. X-ray diffraction, 2 ligands (PHQ, NH2). MolNFT v1 #141467 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5Z8H
- Type
- protein
- Length
- 340 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Adenomatous polyposis COLI protein; Peptide inhibitor
- UniProt
- P25054
- Ligands
- PHQ, NH2
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Adenomatous polyposis COLI protein | protein | 333 | 74% helix, 0% strand | P25054 |
| B | Peptide inhibitor | protein | 7 | 0% helix, 0% strand | — |
Ligands and binding sites
- PHQ · benzyl chlorocarbonate · ligand · chains A, B
- NH2 · Amino group · ion · chains B
- GOL · Glycerol · additive · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Interfaces
1 interface between chains.
- A–B · 639 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent (covalent ligand).
Compared structures
- 5Z8H · APC with an inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25054
- Elsewhere: RCSB PDB 5Z8H · PDBe 5Z8H · UniProt P25054
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