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Crystal structure of galactosyltransferase lgtc in complex with mn and udp-2F-galactose

Analyse Crystal structure of galactosyltransferase lgtc in complex with mn and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1G9R
Type: protein
Length: 278 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Glycosyl transferase
EC: 2.4.1.-
UniProt: P96945
Ligands: UPF, MN
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Glycosyl transferase (EC 2.4.1.-)	protein	278	40% helix, 16% strand	P96945

Ligands and binding sites

UPF · Uridine-5'-diphosphate-2-deoxy-2-fluorogalactose · ligand · chains A
MN · Manganese (II) ion · metal · chains A
ACY · Acetic acid · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	285	0.72	0.86	41	UPF, ACY
2	76	0.41	0.79	16	empty

Modifications

Observed in the structure: 7 modified (engineered).

Compared structures

1G9R · Crystal structure of galactosyltransferase lgtc in complex with mn and udp-2F-galactose · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P96945
Elsewhere: RCSB PDB 1G9R · PDBe 1G9R · UniProt P96945

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