Research workbench
HIS57ALA mutant of cholera toxin B-penatmer
Analyse HIS57ALA mutant of cholera toxin B-penatmer in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G8Z
- Type
- protein
- Length
- 515 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cholera toxin B protein
- UniProt
- P01556
- Ligands
- GAL
- Pockets
- 7 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 25% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, E, F, G, H | Cholera toxin B protein | protein | 103 | 25% helix, 36% strand | P01556 |
Ligands and binding sites
- GAL · beta-D-galactopyranose · sugar · 4 copies · chains D, F, G, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1009 | 0.76 | 0.78 | 46 | empty |
| 2 | 58 | 0.47 | 0.85 | 20 | empty |
| 3 | 53 | 0.45 | 0.85 | 17 | empty |
| 4 | 61 | 0.44 | 0.83 | 21 | empty |
| 5 | 63 | 0.36 | 0.78 | 17 | GAL |
Interfaces
5 interfaces between chains.
- F–G · 1321 Ų buried · 24 hydrogen bonds · protein-protein
- G–H · 1317 Ų buried · 25 hydrogen bonds · protein-protein
- D–E · 1282 Ų buried · 23 hydrogen bonds · protein-protein
- D–H · 1266 Ų buried · 18 hydrogen bonds · protein-protein
- E–F · 1227 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01556
- Elsewhere: RCSB PDB 1G8Z · PDBe 1G8Z · UniProt P01556
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.