UniProt P01556
Cholera enterotoxin subunit B (P01556)
Cholera enterotoxin subunit B (UniProt P01556): 48 experimental structures and 1 predicted model on GenesisL1, 14 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P01556
- Protein
- Cholera enterotoxin subunit B
- Experimental structures
- 48
- Predicted models
- 1
- Ligands
- 14
- Pockets
- 42 · 4 records with a druggable one
Structures
49 records of P01556 in the MolNFT archive: 48 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CHP | Surprising leads for a cholera toxin receptor binding antagonist; crystallographic studies of ctb… | x-ray diffraction | D, E, F, G, H | — | — |
| 1CHP | Surprising leads for a cholera toxin receptor binding antagonist; crystallographic studies of ctb… | x-ray diffraction | D, E, F, G, H | — | — |
| 1CHQ | Surprising leads for a cholera toxin receptor binding antagonist; crystallographic studies of ctb… | x-ray diffraction | D, E, F, G, H | — | — |
| 1CHQ | Surprising leads for a cholera toxin receptor binding antagonist; crystallographic studies of ctb… | x-ray diffraction | D, E, F, G, H | — | — |
| 1CT1 | Cholera toxin B-pentamer mutant G33R bound to receptor pentasaccharide | x-ray diffraction | D, E, F, G, H | — | — |
| 1CT1 | Cholera toxin B-pentamer mutant G33R bound to receptor pentasaccharide | x-ray diffraction | D, E, F, G, H | — | — |
| 1FGB | TOXIN | x-ray diffraction | D, E, F, G, H | — | — |
| 1FGB | TOXIN | x-ray diffraction | D, E, F, G, H | — | — |
| 1G8Z | HIS57ALA mutant of cholera toxin B-penatmer | x-ray diffraction | D, E, F, G, H | — | — |
| 1G8Z | HIS57ALA mutant of cholera toxin B-penatmer | x-ray diffraction | D, E, F, G, H | — | — |
| 1JR0 | Cholera toxin B-pentamer with ligand bmsc-0011 | x-ray diffraction | D, E, F, G, H | — | — |
| 1JR0 | Cholera toxin B-pentamer with ligand bmsc-0011 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RCV | Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV1 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RCV | Cholera toxin B-pentamer complexed with bivalent nitrophenol-galactoside ligand BV1 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RD9 | Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV2 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RD9 | Cholera toxin B-pentamer complexed with bivalent nitrophenol-galactoside ligand BV2 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RDP | Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV3 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RDP | Cholera toxin B-pentamer complexed with bivalent nitrophenol-galactoside ligand BV3 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RF2 | Cholera Toxin B-Pentamer Complexed With Bivalent Nitrophenol-Galactoside Ligand BV4 | x-ray diffraction | D, E, F, G, H | — | — |
| 1RF2 | Cholera toxin B-pentamer complexed with bivalent nitrophenol-galactoside ligand BV4 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5B | Cholera holotoxin with an A-subunit Y30S mutation Form 3 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5B | Cholera holotoxin with an a-subunit Y30S mutation form 3 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5C | Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 1 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5C | Cholera holotoxin with an a-subunit Y30S mutation, crystal form 1 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5D | Cholera holotoxin with an A-subunit Y30S mutation, Crystal form 2 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5D | Cholera holotoxin with an a-subunit Y30S mutation, crystal form 2 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5E | Cholera holotoxin, Crystal form 1 | x-ray diffraction | D, E, F, G, H, J, K, L, M, N | — | — |
| 1S5E | Cholera holotoxin, crystal form 1 | x-ray diffraction | D, E, F, G, H, J, K, L, M, N | — | — |
| 1S5F | Cholera holotoxin, Crystal form 2 | x-ray diffraction | D, E, F, G, H | — | — |
| 1S5F | Cholera holotoxin, crystal form 2 | x-ray diffraction | D, E, F, G, H | — | — |
| 1XTC | Cholera toxin | x-ray diffraction | D, E, F, G, H | — | — |
| 1XTC | Cholera toxin | x-ray diffraction | D, E, F, G, H | — | — |
| 2CHB | Cholera toxin B-pentamer complexed with GM1 pentasaccharide | x-ray diffraction | D, E, F, G, H | — | — |
| 2CHB | Cholera toxin B-pentamer complexed with GM1 pentasaccharide | x-ray diffraction | D, E, F, G, H | — | — |
| 3CHB | Cholera toxin B-pentamer complexed with GM1 pentasaccharide | x-ray diffraction | D, E, F, G, H | — | — |
| 3CHB | Cholera toxin B-pentamer complexed with GM1 pentasaccharide | x-ray diffraction | D, E, F, G, H | — | — |
| 5ELC | Cholera toxin El Tor B-pentamer in complex with Lewis-y | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | NDG, GAL, FUC, NAG, CA, BCN | — |
| 5ELC | Cholera toxin el tor B-pentamer in complex with lewis-Y | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5ELE | Cholera toxin El Tor B-pentamer in complex with A Lewis-y | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | NDG, GAL, FUC, A2G, CA, BCN | — |
| 5ELE | Cholera toxin el tor B-pentamer in complex with a lewis-Y | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5ELF | Cholera toxin El Tor B-pentamer in complex with A-pentasaccharide | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | GLC, GAL, FUC, A2G, BGC, CA | — |
| 5ELF | Cholera toxin el tor B-pentamer in complex with a-pentasaccharide | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 5LZG | Cholera toxin El Tor B-pentamer in complex with inhibitor PC262 | x-ray diffraction | A, B, C, D, E | 7BN | 10 (best 0.75) |
| 5LZG | Cholera toxin el tor B-pentamer in complex with inhibitor PC262 | x-ray diffraction | A, B, C, D, E | 7BN | — |
| 5LZJ | Cholera toxin El Tor B-pentamer in complex with inhibitor Laura237 | x-ray diffraction | A, B, C, D, E | SO4, 7BT | 9 (best 0.74) |
| 5LZJ | Cholera toxin el tor B-pentamer in complex with inhibitor LAURA237 | x-ray diffraction | A, B, C, D, E | SO4, 7BT | — |
| 8OXS | Cholera holotoxin variant (chimera with E. coli heat-labile enterotoxin, 4 C-terminal substitutions) | x-ray diffraction | D, E, F, G, H, C, I, J, K, L | GLA, GAL | 15 (best 0.81) |
| 8QRE | Cholera holotoxin (wildtype) | x-ray diffraction | D, E, F, G, H, C, I, J, K, L | GAL, NA, GLA | 8 (best 0.79) |
| P01556 | AlphaFold monomer V2.0 prediction for cholera enterotoxin subunit B (P01556) | predicted | A | — | — |
Ligands
- GAL · beta-D-galactopyranose · in 5 records
- BCN · Bicine · in 3 records
- CA · Calcium ion · in 3 records
- FUC · alpha-L-fucopyranose · in 3 records
- 7BN · (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3, 4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid · in 2 records
- 7BT · (~{Z})-~{N}-[2-[(2~{R},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethyl]-3-(3,4,5-trimethoxyphenyl)prop-2-enamide · in 2 records
- A2G · 2-acetamido-2-deoxy-alpha-D-galactopyranose · in 2 records
- GLA · alpha-D-galactopyranose · in 2 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 2 records
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · in 2 records
- SO4 · Sulfate ion · in 2 records
- BGC · beta-D-glucopyranose · in 1 record
- GLC · alpha-D-glucopyranose · in 1 record
- NA · Sodium ion · in 1 record
Experiment against prediction
- 5ELE chain B against the predicted model P01556: TM-score 0.99, RMSD 0.29 Å
- 5ELE chain B against the predicted model P01556: TM-score 0.99, RMSD 0.29 Å
- 1CHP chain F against the predicted model P01556: TM-score 0.99, RMSD 0.32 Å
- 1CHP chain F against the predicted model P01556: TM-score 0.99, RMSD 0.32 Å
- 5ELC chain A against the predicted model P01556: TM-score 0.99, RMSD 0.32 Å
- 5ELC chain A against the predicted model P01556: TM-score 0.99, RMSD 0.32 Å
- 5ELE chain D against the predicted model P01556: TM-score 0.99, RMSD 0.34 Å
- 5ELE chain D against the predicted model P01556: TM-score 0.99, RMSD 0.34 Å
- 1CT1 chain F against the predicted model P01556: TM-score 0.99, RMSD 0.35 Å
- 1CT1 chain F against the predicted model P01556: TM-score 0.99, RMSD 0.35 Å
Elsewhere
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