Crystal structure of human 14-3-3 sigma in complex with task-3 peptide and stabilisator fusicoccin a

Structure

x-ray diffraction · 2 distinct chains · 76% helix, 0% strand (DSSP).

Ligands and binding sites

• FSC · Fusicoccin · ligand · chains A, P
• MG · Magnesium ion · metal · 4 copies · chains A
• CA · Calcium ion · metal · chains A
• CL · Chloride ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–P · 545 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 modified (oxidation, phosphorylation).

Compared structures

• 3P1O · Crystal structure of human 14-3-3 sigma in complex with TASK-3 peptide and stabilisator… · the same entry in another collection · chain A against A, TM-score 1.00
• P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
• Q9NPC2 · AlphaFold monomer V2.0 prediction for potassium channel subfamily K member 9 (Q9NPC2) · a predicted model of the same protein · chain P against A, TM-score 0.63

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P31947
• Every structure of UniProt Q9NPC2
• Elsewhere: RCSB PDB 3P1O · PDBe 3P1O · UniProt P31947 · UniProt Q9NPC2