Research workbench
Annexin V complex with heparin oligosaccharides
Analyse Annexin V complex with heparin oligosaccharides in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1G5N
- Type
- protein
- Length
- 318 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Annexin V
- UniProt
- P14668
- Ligands
- UAP, SGN, IDS, CA
- Pockets
- 4 · best druggability 0.54
Structure
x-ray diffraction · 1 distinct chain · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Annexin V | protein | 318 | 71% helix, 0% strand | P14668 |
Ligands and binding sites
- UAP · 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid · ligand · 2 copies · chains A
- SGN · 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose · sugar · 4 copies · chains A
- IDS · 2-O-sulfo-alpha-L-idopyranuronic acid · sugar · 2 copies · chains A
- CA · Calcium ion · metal · 9 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 96 | 0.54 | 0.84 | 25 | empty |
| 2 | 108 | 0.51 | 0.82 | 21 | empty |
| 3 | 145 | 0.45 | 0.76 | 18 | empty |
| 4 | 71 | 0.38 | 0.78 | 15 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P14668
- Elsewhere: RCSB PDB 1G5N · PDBe 1G5N · UniProt P14668
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