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1.60 a crystal structure of the gating domain from small conductance potassium channel complexed with calcium-calmodulin

Analyse 1.60 a crystal structure of the gating domain from small conductance potassium… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1G4Y
Type: protein
Length: 228 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calcium-activated potassium channel RSK2; Calmodulin
UniProt: P70604, P62161
Ligands: CA, SO4
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 63% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B	Calcium-activated potassium channel RSK2	protein	81	81% helix, 1% strand	P70604
R	Calmodulin	protein	147	53% helix, 6% strand	P62161

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains R
SO4 · Sulfate ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.46	0.82	18	empty

Interfaces

1 interface between chains.

B–R · 1269 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1G4Y · 1.60 a crystal structure of the gating domain from small conductance potassium channel… · the same entry in another collection · chain B against B, TM-score 1.00
P70604 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain B against A, TM-score 0.75

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P70604
Every structure of UniProt P62161
Elsewhere: RCSB PDB 1G4Y · PDBe 1G4Y · UniProt P70604 · UniProt P62161

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