Research workbench
Crystal structure of heptp with an open wpd loop and partially depleted active site
Analyse Crystal structure of heptp with an open wpd loop and partially depleted active… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3O4T
- Type
- protein
- Length
- 281 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 7
- EC
- 3.1.3.48
- UniProt
- P35236
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 7 (EC 3.1.3.48) | protein | 281 | 36% helix, 22% strand | P35236 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · chains A
- GOL · Glycerol · additive · 2 copies · chains A
- TAR · D(-)-tartaric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 78 | 0.34 | 0.76 | 20 | empty |
Compared structures
- 3O4T · Crystal Structure of HePTP with an Open WPD Loop and Partially Depleted Active Site · the same entry in another collection · chain A against A, TM-score 1.00
- P35236 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 7… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35236
- Elsewhere: RCSB PDB 3O4T · PDBe 3O4T · UniProt P35236
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