UniProt P35236
Tyrosine-protein phosphatase non-receptor type 7 (P35236)
Tyrosine-protein phosphatase non-receptor type 7 (UniProt P35236): 24 experimental structures and 1 predicted model on GenesisL1, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P35236
- Protein
- Tyrosine-protein phosphatase non-receptor type 7
- Experimental structures
- 24
- Predicted models
- 1
- Pockets
- 3 · 0 records with a druggable one
Structures
25 records of P35236 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1ZC0 | Crystal structure of human hematopoietic tyrosine phosphatase (HePTP) catalytic domain | x-ray diffraction | A | — | — |
| 1ZC0 | Crystal structure of human hematopoietic tyrosine phosphatase (heptp) catalytic domain | x-ray diffraction | A | — | — |
| 2GP0 | HePTP Catalytic Domain (residues 44-339), S225D mutant | x-ray diffraction | A | — | — |
| 2GP0 | Heptp catalytic domain (residues 44-339), S225D mutant | x-ray diffraction | A | — | — |
| 2GPH | Docking motif interactions in the MAP kinase ERK2 | x-ray diffraction | B | — | — |
| 2GPH | Docking motif interactions in the MAP kinase ERK2 | x-ray diffraction | B | — | — |
| 2HVL | Crystal structure of the HePTP catalytic domain C270S mutant | x-ray diffraction | A | — | — |
| 2HVL | Crystal structure of the heptp catalytic domain C270S mutant | x-ray diffraction | A | — | — |
| 2QDC | Crystal structure of the HePTP catalytic domain D236A mutant | x-ray diffraction | A | — | — |
| 2QDC | Crystal structure of the heptp catalytic domain D236A mutant | x-ray diffraction | A | — | — |
| 2QDM | Crystal structure of the HePTP catalytic domain C270S/D236A/Q314A mutant | x-ray diffraction | A | — | — |
| 2QDM | Crystal structure of the heptp catalytic domain C270S/D236A/Q314A mutant | x-ray diffraction | A | — | — |
| 2QDP | Crystal structure of the HePTP catalytic domain C270S mutant crystallized in ammonium acetate | x-ray diffraction | A | — | — |
| 2QDP | Crystal structure of the heptp catalytic domain C270S mutant crystallized in ammonium acetate | x-ray diffraction | A | — | — |
| 3D42 | Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide | x-ray diffraction | A | — | — |
| 3D42 | Crystal structure of heptp in complex with a monophosphorylated ERK2 peptide | x-ray diffraction | A | — | — |
| 3D44 | Crystal structure of HePTP in complex with a dually phosphorylated Erk2 peptide mimetic | x-ray diffraction | A | — | — |
| 3D44 | Crystal structure of heptp in complex with a dually phosphorylated ERK2 peptide mimetic | x-ray diffraction | A | — | — |
| 3O4S | Crystal Structure of HePTP with a Closed WPD Loop and an Ordered E-Loop | x-ray diffraction | A | — | — |
| 3O4S | Crystal structure of heptp with a closed wpd loop and an ordered E- loop | x-ray diffraction | A | — | — |
| 3O4T | Crystal Structure of HePTP with an Open WPD Loop and Partially Depleted Active Site | x-ray diffraction | A | — | — |
| 3O4T | Crystal structure of heptp with an open wpd loop and partially depleted active site | x-ray diffraction | A | — | — |
| 3O4U | Crystal Structure of HePTP with an Atypically Open WPD Loop | x-ray diffraction | A | — | — |
| 3O4U | Crystal structure of heptp with an atypically open wpd loop | x-ray diffraction | A | — | — |
| P35236 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 7 (P35236) | predicted | A | — | 3 (best 0.45) |
Experiment against prediction
- 2HVL chain A against the predicted model P35236: TM-score 0.99, RMSD 0.59 Å
- 2HVL chain A against the predicted model P35236: TM-score 0.99, RMSD 0.59 Å
- 2QDC chain A against the predicted model P35236: TM-score 0.99, RMSD 0.61 Å
- 2QDC chain A against the predicted model P35236: TM-score 0.99, RMSD 0.61 Å
- 1ZC0 chain A against the predicted model P35236: TM-score 0.99, RMSD 0.68 Å
- 1ZC0 chain A against the predicted model P35236: TM-score 0.99, RMSD 0.68 Å
- 2GP0 chain A against the predicted model P35236: TM-score 0.99, RMSD 0.69 Å
- 2GP0 chain A against the predicted model P35236: TM-score 0.99, RMSD 0.69 Å
- 3O4U chain A against the predicted model P35236: TM-score 0.99, RMSD 0.74 Å
- 3O4U chain A against the predicted model P35236: TM-score 0.99, RMSD 0.74 Å
Elsewhere
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