MolNFT v1 · #319661 · protein
AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 7 (P35236)
P35236: “AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 7 (P35236)”. 3 pockets (best druggability 0.45). MolNFT v1 #319661 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P35236
- Type
- protein
- Length
- 360 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xf1770e5260EEBa91B7A9E674F368eD787DE8992D
- Molecule
- Tyrosine-protein phosphatase non-receptor type 7
- UniProt
- P35236
- Pockets
- 3 · best druggability 0.45
Structure
1 distinct chain · 31% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 7 | protein | 360 | 31% helix, 18% strand | P35236 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 116 | 0.45 | 0.78 | 28 | empty |
| 2 | 77 | 0.31 | 0.74 | 21 | empty |
| 3 | 53 | 0.29 | 0.76 | 14 | empty |
Compared structures
- 2QDP · Crystal structure of the HePTP catalytic domain C270S mutant crystallized in ammonium… · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 2QDP · Crystal structure of the heptp catalytic domain C270S mutant crystallized in ammonium… · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 3O4S · Crystal structure of heptp with a closed wpd loop and an ordered E- loop · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 3O4S · Crystal Structure of HePTP with a Closed WPD Loop and an Ordered E-Loop · an experimental structure of the same protein · chain A against A, TM-score 0.80
- 2GP0 · Heptp catalytic domain (residues 44-339), S225D mutant · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 2GP0 · HePTP Catalytic Domain (residues 44-339), S225D mutant · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3D42 · Crystal structure of heptp in complex with a monophosphorylated ERK2 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 3D42 · Crystal structure of HePTP in complex with a monophosphorylated Erk2 peptide · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 1ZC0 · Crystal structure of human hematopoietic tyrosine phosphatase (HePTP) catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 1ZC0 · Crystal structure of human hematopoietic tyrosine phosphatase (heptp) catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 2HVL · Crystal structure of the HePTP catalytic domain C270S mutant · an experimental structure of the same protein · chain A against A, TM-score 0.79
- 2HVL · Crystal structure of the heptp catalytic domain C270S mutant · an experimental structure of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35236
- Elsewhere: UniProt P35236 · AlphaFold DB P35236
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