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Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex with a carbon-linked proline isostere inhibitor (34)
Analyse Crystal structure of insulin-like growth factor 1 receptor (igf-1R-wt) complex… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NW7
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor 1 receptor
- EC
- 2.7.10.1
- UniProt
- P08069
- Ligands
- LGV
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 39% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor 1 receptor (EC 2.7.10.1) | protein | 297 | 39% helix, 15% strand | P08069 |
Ligands and binding sites
- LGV · N-({4-[(3-cyclopropyl-1H-pyrazol-5-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}methyl)-6-fluoropyridine-3-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 180 | 0.70 | 0.88 | 29 | LGV |
| 2 | 153 | 0.44 | 0.75 | 19 | empty |
| 3 | 99 | 0.41 | 0.77 | 24 | empty |
| 4 | 64 | 0.31 | 0.75 | 14 | empty |
| 5 | 68 | 0.28 | 0.73 | 18 | empty |
Compared structures
- 3NW7 · Crystal structure of insulin-like growth factor 1 receptor (IGF-1R-WT) complex with a… · the same entry in another collection · chain A against A, TM-score 1.00
- P08069 · AlphaFold monomer V2.0 prediction for insulin-like growth factor 1 receptor (P08069) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08069
- Elsewhere: RCSB PDB 3NW7 · PDBe 3NW7 · UniProt P08069
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