Research workbench
Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4)
Analyse Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3NFH
- Type
- protein
- Length
- 423 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-directed RNA polymerase I subunit RPA49
- EC
- 2.7.7.6
- UniProt
- Q01080
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 55% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase I subunit RPA49 (EC 2.7.7.6) | protein | 207 | 57% helix, 7% strand | Q01080 |
| B | DNA-directed RNA polymerase I subunit RPA49 (EC 2.7.7.6) | protein | 216 | 54% helix, 8% strand | Q01080 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 417 | 0.69 | 0.81 | 50 | empty |
| 2 | 166 | 0.41 | 0.73 | 26 | empty |
| 3 | 68 | 0.36 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 817 Ų buried · 12 hydrogen bonds · protein-protein
Compared structures
- 3NFH · Crystal structure of tandem winged helix domain of RNA polymerase I subunit A49 (P4) · the same entry in another collection · chain A against A, TM-score 1.00
- Q01080 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase I subunit RPA49 (Q01080) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q01080
- Elsewhere: RCSB PDB 3NFH · PDBe 3NFH · UniProt Q01080
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