Research workbench
Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A
Analyse Crystal structure of the agonist form of mouse glucocorticoid receptor… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3MNO
- Type
- protein
- Length
- 265 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glucocorticoid receptor; Nuclear receptor coactivator 2 peptide
- UniProt
- P06537, Q61026
- Ligands
- DEX, SCN
- Pockets
- 2 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 66% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glucocorticoid receptor | protein | 255 | 66% helix, 5% strand | P06537 |
| B | Nuclear receptor coactivator 2 peptide | protein | 10 | 70% helix, 0% strand | Q61026 |
Ligands and binding sites
- DEX · Dexamethasone · ligand · chains A
- SCN · Thiocyanate ion · ion · 2 copies · chains A
- GOL · Glycerol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 174 | 0.83 | 0.97 | 22 | DEX |
| 2 | 142 | 0.67 | 0.88 | 20 | GOL |
Interfaces
1 interface between chains.
- A–B · 587 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 3MNO · Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by… · the same entry in another collection · chain A against A, TM-score 1.00
- P06537 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P06537) · a predicted model of the same protein · chain A against A, TM-score 0.95
- Q61026 · AlphaFold monomer V2.0 prediction for nuclear receptor coactivator 2 (Q61026) · a predicted model of the same protein · chain B against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06537
- Every structure of UniProt Q61026
- Elsewhere: RCSB PDB 3MNO · PDBe 3MNO · UniProt P06537 · UniProt Q61026
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