Research workbench
Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate
Analyse Co-crystal structure of protein farnesyltransferase complexed with a farnesyl… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1FT2
- Type
- protein
- Length
- 716 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein farnesyltransferase
- EC
- 2.5.1.-
- UniProt
- Q04631, Q02293
- Ligands
- FPP, ZN
- Pockets
- 11 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein farnesyltransferase (EC 2.5.1.-) | protein | 315 | 70% helix, 1% strand | Q04631 |
| B | Protein farnesyltransferase (EC 2.5.1.-) | protein | 401 | 51% helix, 5% strand | Q02293 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1041 | 0.77 | 0.79 | 73 | ZN, FPP |
| 2 | 277 | 0.73 | 0.86 | 46 | empty |
| 3 | 57 | 0.68 | 0.96 | 17 | empty |
| 4 | 209 | 0.55 | 0.78 | 29 | empty |
| 5 | 178 | 0.50 | 0.77 | 23 | empty |
Interfaces
1 interface between chains.
- A–B · 3527 Ų buried · 75 hydrogen bonds · protein-protein
Compared structures
- 1FT2 · Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate… · the same entry in another collection · chain A against A, TM-score 1.00
- Q04631 · AlphaFold monomer V2.0 prediction for protein FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERAS… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q02293 · AlphaFold monomer V2.0 prediction for protein farnesyltransferase subunit beta (Q02293) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04631
- Every structure of UniProt Q02293
- Elsewhere: RCSB PDB 1FT2 · PDBe 1FT2 · UniProt Q04631 · UniProt Q02293
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