Research workbench
Crystal structure of human yap and tead complex
Analyse Crystal structure of human yap and tead complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3KYS
- Type
- protein
- Length
- 518 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-1; 65 kda yes-associated protein
- UniProt
- P28347, P46937
- Pockets
- 5 · best druggability 0.51
Structure
x-ray diffraction · 4 distinct chains · 21% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-1 | protein | 208 | 17% helix, 53% strand | P28347 |
| B | 65 kda yes-associated protein | protein | 50 | 40% helix, 12% strand | P46937 |
| C | Transcriptional enhancer factor tef-1 | protein | 211 | 18% helix, 50% strand | P28347 |
| D | 65 kda yes-associated protein | protein | 49 | 35% helix, 8% strand | P46937 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.51 | 0.79 | 25 | empty |
| 2 | 98 | 0.36 | 0.75 | 17 | empty |
| 3 | 70 | 0.31 | 0.75 | 16 | empty |
| 4 | 61 | 0.31 | 0.75 | 14 | empty |
| 5 | 63 | 0.28 | 0.73 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1771 Ų buried · 25 hydrogen bonds · protein-protein
- C–D · 1668 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 695 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (nonstandard).
Compared structures
- 3KYS · Crystal structure of human YAP and TEAD complex · the same entry in another collection · chain D against D, TM-score 1.00
- P28347 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-1 (P28347) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P46937 · AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) · a predicted model of the same protein · chain B against A, TM-score 0.44
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28347
- Every structure of UniProt P46937
- Elsewhere: RCSB PDB 3KYS · PDBe 3KYS · UniProt P28347 · UniProt P46937
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.