UniProt P28347
Transcriptional enhancer factor TEF-1 (P28347)
Transcriptional enhancer factor TEF-1 (UniProt P28347): 18 experimental structures on GenesisL1, 5 ligands bound, 28 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P28347
- Protein
- Transcriptional enhancer factor TEF-1
- Experimental structures
- 18
- Predicted models
- 0
- Ligands
- 5
- Pockets
- 28 · 2 records with a druggable one
Structures
18 records of P28347 in the MolNFT archive: 18 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2HZD | NMR structure of the DNA-binding TEA domain and insights into TEF-1 function | solution nmr | A | — | — |
| 2HZD | NMR structure of the DNA-binding tea domain and insights into tef-1 function | solution nmr | A | — | — |
| 3KYS | Crystal structure of human YAP and TEAD complex | x-ray diffraction | A, C | — | — |
| 3KYS | Crystal structure of human yap and tead complex | x-ray diffraction | A, C | — | — |
| 4RE1 | Crystal structure of human TEAD1 and disulfide-engineered YAP | x-ray diffraction | A, B | — | — |
| 4RE1 | Crystal structure of human TEAD1 and disulfide-engineered yap | x-ray diffraction | A, B | — | — |
| 4Z8E | TEAD DBD mutant -deltaL1 | x-ray diffraction | A, B, C | — | — |
| 4Z8E | Tead dbd mutant -DELTAL1 | x-ray diffraction | A, B, C | — | — |
| 5NNX | TEAD1 bound to DNA | x-ray diffraction | A | — | 3 (best 0.46) |
| 5NNX | TEAD1 bound to DNA | x-ray diffraction | A | — | — |
| 6HIL | X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural… | x-ray diffraction | A, D, B, C | MYR | 18 (best 0.82) |
| 6HIL | X-ray structure of TEAD1(Y421H mutant) complexed with YAP(WILDTYPE): molecular and structural… | x-ray diffraction | A, D, B, C | MYR | — |
| 6IM5 | YAP-binding domain of human TEAD1 | x-ray diffraction | A, B | PO4 | — |
| 6IM5 | Yap-binding domain of human TEAD1 | x-ray diffraction | A, B | PO4 | — |
| 7CMM | Crystal structure of TEAD1-ybd in complex with K-975 | x-ray diffraction | A, B, C, D | KK9 | — |
| 7ZJP | Optimization of TEAD P-Site Binding Fragment Hit into In Vivo Active Lead MSC-4106 | x-ray diffraction | A, B | JJU, SO4 | 7 (best 0.83) |
| 7ZJP | Optimization of tead P-site binding fragment hit into in vivo active lead msc-4106 | x-ray diffraction | A, B | JJU, SO4 | — |
| P28347 | AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-1 (P28347) | — | — | — |
Ligands
Elsewhere
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