UniProt P46937
Transcriptional coactivator YAP1 (P46937)
Transcriptional coactivator YAP1 (UniProt P46937): 47 experimental structures on GenesisL1, 2 ligands bound, 11 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P46937
- Protein
- Transcriptional coactivator YAP1
- Experimental structures
- 47
- Predicted models
- 0
- Ligands
- 2
- Pockets
- 11 · 2 records with a druggable one
Structures
47 records of P46937 in the MolNFT archive: 47 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1JMQ | YAP65 (L30K mutant) WW domain in Complex with GTPPPPYTVG peptide | solution nmr | A | — | — |
| 1JMQ | YAP65 (L30K mutant) ww domain in complex with gtppppytvg peptide | solution nmr | A | — | — |
| 1K5R | YAP65 WW domain S24-Amino-Ethylsulfanyl-Acetic Acid mutant | solution nmr | A | — | — |
| 1K5R | YAP65 ww domain S24-amino-ethylsulfanyl-acetic acid mutant | solution nmr | A | — | — |
| 1K9Q | YAP65 WW domain complexed to N-(n-octyl)-GPPPY-NH2 | solution nmr | A | — | — |
| 1K9Q | YAP65 ww domain complexed to N-(N-octyl)-gpppy-NH2 | solution nmr | A | — | — |
| 1K9R | YAP65 WW domain complexed to Acetyl-PLPPY | solution nmr | A | — | — |
| 1K9R | YAP65 ww domain complexed to acetyl-plppy | solution nmr | A | — | — |
| 2LAW | Structure of the second WW domain from human YAP in complex with a human Smad1 derived peptide | solution nmr | A | — | — |
| 2LAW | Structure of the second ww domain from human yap in complex with a human SMAD1 derived peptide | solution nmr | A | — | — |
| 2LAX | Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated… | solution nmr | A | — | — |
| 2LAX | Structure of first ww domain of human yap in complex with a human SMAD1 doubly-phosphorilated… | solution nmr | A | — | — |
| 2LAY | Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived… | solution nmr | A | — | — |
| 2LAY | Structure of the first ww domain of human yap in complex with a phosphorylated human SMAD1 derived… | solution nmr | A | — | — |
| 2LTV | YAP WW2 in complex with a Smad7 derived peptide | solution nmr | A | — | — |
| 2LTV | Yap WW2 in complex with a SMAD7 derived peptide | solution nmr | A | — | — |
| 2LTW | YAP WW1 in complex with a Smad7 derived peptide | solution nmr | A | — | — |
| 2LTW | Yap WW1 in complex with a SMAD7 derived peptide | solution nmr | A | — | — |
| 3KYS | Crystal structure of human YAP and TEAD complex | x-ray diffraction | B, D | — | — |
| 3KYS | Crystal structure of human yap and tead complex | x-ray diffraction | B, D | — | — |
| 4RE1 | Crystal structure of human TEAD1 and disulfide-engineered YAP | x-ray diffraction | C, D | — | — |
| 4RE1 | Crystal structure of human TEAD1 and disulfide-engineered yap | x-ray diffraction | C, D | — | — |
| 4REX | Crystal structure of the first WW domain of human YAP2 isoform | x-ray diffraction | A | — | — |
| 4REX | Crystal structure of the first ww domain of human YAP2 isoform | x-ray diffraction | A | — | — |
| 5OAQ | TEAD4 complexed with yap peptide and myristate (covalently bound) | x-ray diffraction | L | — | — |
| 5OAQ | TEAD4 complexed with yap peptide and myristate (covalently bound) | x-ray diffraction | L | — | — |
| 6G6X | 14-3-3SIGMA in complex with a P129BETA3P mutated yap PS127 phosphopeptide | x-ray diffraction | P | EOE | — |
| 6G8P | 14-3-3sigma in complex with a P129beta3P and L132beta3L mutated YAP pS127 phosphopeptide | x-ray diffraction | P | — | 1 (best 0.52) |
| 6G8P | 14-3-3SIGMA in complex with a P129BETA3P and L132BETA3L mutated yap PS127 phosphopeptide | x-ray diffraction | P | EOE | — |
| 6G8Q | 14-3-3SIGMA in complex with a A130BETA3A and Q133BETA3Q mutated yap PS127 phosphopeptide | x-ray diffraction | P | — | — |
| 6GE3 | X-ray structure of TEAD4 (wildtype) complexed with YAP (wildtype): The role of residual flexibility… | x-ray diffraction | L | — | 1 (best 0.31) |
| 6GE3 | X-ray structure of TEAD4 (wildtype) complexed with yap (wildtype): the role of residual flexibility… | x-ray diffraction | L | — | — |
| 6GE4 | TEAD4 (216-434);E263A complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | L | — | — |
| 6GE5 | TEAD4 (216-434);Y429F complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | L | — | — |
| 6GE6 | X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(wildtype): The role of residual… | x-ray diffraction | L | — | 3 (best 0.40) |
| 6GE6 | X-ray structure of TEAD4(E263A+Y429F mutant) complexed with YAP(WILDTYPE): the role of residual… | x-ray diffraction | L | — | — |
| 6GEC | TEAD4 (216-434) complexed with yap peptide (60-100);S94A and myristoate (covalently bound) at 1.70A… | x-ray diffraction | L | ACE | — |
| 6GEE | TEAD4 (216-434);E263A complexed with yap peptide (60-100); S94A and myristoate (covalently bound)… | x-ray diffraction | L | ACE | — |
| 6GEG | TEAD4 (216-434);Y429F complexed with yap peptide (60-100); S94A and myristoate (covalently bound)… | x-ray diffraction | L | ACE | — |
| 6GEI | TEAD4 (216-434);E263A+Y429F complexed with yap peptide (60- 100);S94A and myristoate (covalently… | x-ray diffraction | L | ACE | — |
| 6GEK | TEAD4 (216-434);Y429F complexed with yap peptide (60-100) and myristoate (covalently bound) at… | x-ray diffraction | L, M | — | — |
| 6HIK | X-ray structure of TEAD4(Y429H) mutant) complexed with YAP (wildtype): Molecular and structural… | x-ray diffraction | L | — | 1 (best 0.34) |
| 6HIK | X-ray structure of TEAD4(Y429H) mutant) complexed with yap (wildtype): molecular and structural… | x-ray diffraction | L | ACE | — |
| 6HIL | X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and structural… | x-ray diffraction | L, O, M, N | — | 5 (best 0.70) |
| 6HIL | X-ray structure of TEAD1(Y421H mutant) complexed with YAP(WILDTYPE): molecular and structural… | x-ray diffraction | L, O, M, N | — | — |
| 6Q2X | TEAD4 (216-434) complexed with yap peptide (60-100) and myristoate (covalently bound) at 2.1A… | x-ray diffraction | L | — | — |
| P46937 | AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) | — | — | — |
Ligands
Elsewhere
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