Isolated ligand binding domain dimer of GLUA2 ionotropic glutamate receptor in complex with glutamate, ly 404187 and zk 200775

Structure

x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).

Ligands and binding sites

• GLU · Glutamic acid · ligand · chains A
• LY7 · N-[(2S)-2-(4'-cyanobiphenyl-4-yl)propyl]propane-2-sulfonamide · ligand · chains A, B
• ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid · ligand · chains B
• SO4 · Sulfate ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 901 Ų buried · 8 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 3KGC · Isolated ligand binding domain dimer of GluA2 ionotropic glutamate receptor in complex… · the same entry in another collection · chain A against A, TM-score 1.00
• P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P19491
• Elsewhere: RCSB PDB 3KGC · PDBe 3KGC · UniProt P19491