Research workbench
Ternary complex of TGF-B1 reveals isoform-specific ligand recognition and receptor recruitment in the superfamily
Analyse Ternary complex of TGF-B1 reveals isoform-specific ligand recognition and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3KFD
- Type
- protein
- Length
- 1,149 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transforming growth factor beta-1; TGF-beta receptor type-2; TGF-beta receptor type-1
- UniProt
- P01137, P37173, P36897
- Pockets
- 19 · best druggability 0.69
Structure
x-ray diffraction · 6 distinct chains · 7% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Transforming growth factor beta-1 | protein | 112 | 19% helix, 44% strand | P01137 |
| E | TGF-beta receptor type-2 | protein | 108 | 3% helix, 43% strand | P37173 |
| F, H | TGF-beta receptor type-2 | protein | 106 | 3% helix, 42% strand | P37173 |
| I, K | TGF-beta receptor type-1 | protein | 66 | 5% helix, 26% strand | P36897 |
| J, L | TGF-beta receptor type-1 | protein | 70 | 9% helix, 37% strand | P36897 |
| G | TGF-beta receptor type-2 | protein | 109 | 3% helix, 44% strand | P37173 |
Pockets
19 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 525 | 0.69 | 0.79 | 57 | empty |
| 2 | 511 | 0.67 | 0.78 | 57 | empty |
| 3 | 240 | 0.57 | 0.78 | 32 | empty |
| 4 | 199 | 0.56 | 0.79 | 28 | empty |
| 5 | 296 | 0.54 | 0.75 | 37 | empty |
Interfaces
23 interfaces between chains.
- A–B · 1401 Ų buried · 10 hydrogen bonds · protein-protein
- C–D · 1399 Ų buried · 10 hydrogen bonds · protein-protein
- C–L · 664 Ų buried · 1 hydrogen bond · protein-protein
- A–J · 658 Ų buried · 1 hydrogen bond · protein-protein
- D–K · 560 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 62 disulfide (disulfide).
Compared structures
- 3KFD · Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01137
- Every structure of UniProt P37173
- Every structure of UniProt P36897
- Elsewhere: RCSB PDB 3KFD · PDBe 3KFD · UniProt P01137 · UniProt P37173 · UniProt P36897
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