UniProt P36897
TGF-beta receptor type-1 (P36897)
TGF-beta receptor type-1 (UniProt P36897), EC 2.7.11.30: 65 experimental structures on GenesisL1, 12 ligands bound, 6 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P36897
- Protein
- TGF-beta receptor type-1
- EC
- 2.7.11.30
- Experimental structures
- 65
- Predicted models
- 0
- Ligands
- 12
- Pockets
- 6 · 3 records with a druggable one
Structures
65 records of P36897 in the MolNFT archive: 65 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1B6C | Crystal structure of the cytoplasmic domain of the type I TGF-beta receptor in complex with FKBP12 | x-ray diffraction | B, D, F, H | — | — |
| 1B6C | Crystal structure of the cytoplasmic domain of the type I TGF-beta receptor in complex with FKBP12 | x-ray diffraction | B, D, F, H | — | — |
| 1IAS | Cytoplasmic domain of unphosphorylated type I TGF-beta receptor crystallized without FKBP12 | x-ray diffraction | A, B, C, D, E | — | — |
| 1IAS | Cytoplasmic domain of unphosphorylated type I TGF-beta receptor crystallized without FKBP12 | x-ray diffraction | A, B, C, D, E | — | — |
| 1PY5 | Crystal Structure of TGF-beta receptor I kinase with inhibitor | x-ray diffraction | A | — | — |
| 1PY5 | Crystal structure of TGF-beta receptor I kinase with inhibitor | x-ray diffraction | A | — | — |
| 1RW8 | Crystal Structure of TGF-beta receptor I kinase with ATP site inhibitor | x-ray diffraction | A | — | — |
| 1RW8 | Crystal structure of TGF-beta receptor I kinase with ATP site inhibitor | x-ray diffraction | A | — | — |
| 1VJY | Crystal Structure of a Naphthyridine Inhibitor of Human TGF-beta Type I Receptor | x-ray diffraction | A | — | — |
| 1VJY | Crystal structure of a naphthyridine inhibitor of human TGF- beta type I receptor | x-ray diffraction | A | — | — |
| 2L5S | Solution structure of the extracellular domain of the TGF-beta type I receptor | solution nmr | A | — | — |
| 2L5S | Solution structure of the extracellular domain of the TGF-beta type I receptor | solution nmr | A | — | — |
| 2PJY | Structural basis for cooperative assembly of the TGF-beta signaling complex | x-ray diffraction | C | — | — |
| 2PJY | Structural basis for cooperative assembly of the TGF-beta signaling complex | x-ray diffraction | C | — | — |
| 2WOT | ALK5 IN COMPLEX WITH 4-((5,6-dimethyl-2-(2-pyridyl)-3-pyridyl)oxy)-N-(3,4,5-trimethoxyphenyl)pyridin… | x-ray diffraction | A | — | — |
| 2WOT | ALK5 in complex with 4-((5,6-dimethyl-2-(2-pyridyl)-3-PYRIDYL)OXY)-N… | x-ray diffraction | A | — | — |
| 2WOU | ALK5 IN COMPLEX WITH 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide | x-ray diffraction | A | — | — |
| 2WOU | ALK5 in complex with 4-((4-((2,6-dimethyl-3-PYRIDYL)OXY)-2-pyridyl) AMINO)BENZENESULFONAMIDE | x-ray diffraction | A | — | — |
| 2X7O | Crystal structure of TGFbRI complexed with an indoli inhibitor | x-ray diffraction | A, B, C, D, E | — | — |
| 2X7O | Crystal structure of tgfbri complexed with an indolinone inhibitor | x-ray diffraction | A, B, C, D, E | — | — |
| 3FAA | Crystal structure of TGFbRI complexed with a 2-aminoimidazole inhibitor | x-ray diffraction | A, B, C, D, E | — | — |
| 3FAA | Crystal structure of tgfbri complexed with a 2-aminoimidazole inhibitor | x-ray diffraction | A, B, C, D, E | — | — |
| 3GXL | ALK-5 kinase complex with GW857175 | x-ray diffraction | A | — | — |
| 3GXL | ALK-5 kinase complex with GW857175 | x-ray diffraction | A | — | — |
| 3HMM | Structure of Alk5 + GW855857 | x-ray diffraction | A | — | — |
| 3HMM | Structure of ALK5 + GW855857 | x-ray diffraction | A | — | — |
| 3KCF | Crystal structure of TGFbRI complexed with a pyrazolone inhibitor | x-ray diffraction | A, B, C, D, E | — | — |
| 3KCF | Crystal structure of tgfbri complexed with a pyrazolone inhibitor | x-ray diffraction | A, B, C, D, E | — | — |
| 3KFD | Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in… | x-ray diffraction | I, J, K, L | — | — |
| 3KFD | Ternary complex of TGF-B1 reveals isoform-specific ligand recognition and receptor recruitment in… | x-ray diffraction | I, J, K, L | — | — |
| 3TZM | TGF-beta Receptor type 1 in complex with SB431542 | x-ray diffraction | A | — | — |
| 3TZM | TGF-beta receptor type 1 in complex with SB431542 | x-ray diffraction | A | — | — |
| 4X0M | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2F | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2F | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2G | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | 3WK, SO4 | 2 (best 0.74) |
| 4X2G | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2J | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2J | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2K | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2K | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 4X2N | Selection of fragments for kinase inhibitor design: decoration is key | x-ray diffraction | A | — | — |
| 5E8S | TGF-beta receptor type 1 kinase domain (wt) | x-ray diffraction | A | — | — |
| 5E8T | TGF-beta receptor type 1 kinase domain (T204D) | x-ray diffraction | A | — | — |
| 5E8T | TGF-beta receptor type 1 kinase domain (T204D) | x-ray diffraction | A | — | — |
| 5E8U | TGF-beta receptor type 1 kinase domain (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) | x-ray diffraction | A | — | 2 (best 0.74) |
| 5E8U | TGF-beta receptor type 1 kinase domain (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) | x-ray diffraction | A | — | — |
| 5E8W | TGF-beta receptor type 1 kinase domain (T204D) in complex with staurosporine | x-ray diffraction | A | STU | — |
| 5E8W | TGF-beta receptor type 1 kinase domain (T204D) in complex with staurosporine | x-ray diffraction | A | — | — |
| 5E8X | TGF-beta receptor type 1 kinase domain (T204D,I211V,Y249F,S280T, Y282F,S287N,A350C,L352F) in… | x-ray diffraction | A | — | — |
| 5E8Z | TGF-beta receptor type 1 kinase domain (T204D) in complex with 3… | x-ray diffraction | A | — | — |
| 5E90 | TGF-beta receptor type 1 kinase domain (T204D,I211V,Y249F, S280T,Y282F,S287N,A350C,L352F) in… | x-ray diffraction | A | 5L4 | — |
| 5E90 | TGF-beta receptor type 1 kinase domain (T204D,I211V,Y249F, S280T, Y282F,S287N,A350C,L352F) in… | x-ray diffraction | A | — | — |
| 5FRI | ALK5 in complex witha an N-(4-anilino-2-PYRIDYL)ACETAMIDE inhibitor. | x-ray diffraction | A | — | — |
| 5QIK | TGF-beta receptor type 1 kinase domain (T204D) in complex with N-{4… | x-ray diffraction | A | J2M | — |
| 5QIL | TGF-beta receptor type 1 kinase domain (T204D) in complex with N-{4… | x-ray diffraction | A | J2V | — |
| 5QIM | TGF-beta receptor type 1 kinase domain (T204D) in complex with N-{4… | x-ray diffraction | A | J2Y | — |
| 5QTZ | TGF-beta receptor type 1 kinase domain (T204D) in complex with 6-[1… | x-ray diffraction | A | QMY | — |
| 5QU0 | TGF-beta receptor type 1 kinase domain (T204D) in complex with… | x-ray diffraction | A | QMV | — |
| 5QU0 | TGF-beta receptor type 1 kinase domain (T204D) in complex with 6-[4… | x-ray diffraction | A | QMV | — |
5 records more on the page itself.
Ligands
- QMV · 6-[4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazol-5-yl]imidazo[1,2-b]pyridazine-3-carbonitrile · in 2 records
- 3WK · 4-[(4-aminophenyl)amino]pyrido[2,3-d]pyrimidin-5(6H)-one · in 1 record
- 5L4 · 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide · in 1 record
- 8LY · N-[2-(5-chloro-2-fluorophenyl)pyridin-4-yl]-2-[(piperidin-4-yl)methyl]-2H-pyrazolo[4,3-b]pyridin-7-amine · in 1 record
- A1IAZ · 2-[5-(1,3-benzodioxol-5-yl)-2-~{tert}-butyl-1~{H}-imidazol-4-yl]-6-methyl-pyridine · in 1 record
- D0A · N-(3-fluoropyridin-4-yl)-2-[6-(trifluoromethyl)pyridin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine · in 1 record
- J2M · N-{4-[3-(6-fluoropyridin-3-yl)-4-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-2-yl]pyridin-2-yl}acetamide · in 1 record
- J2V · N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide · in 1 record
- J2Y · N-{4-[3-(5-methoxypyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide · in 1 record
- QMY · 6-[1-(2,2-difluoroethyl)-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl]imidazo[1,2-a]pyridine · in 1 record
- SO4 · Sulfate ion · in 1 record
- STU · Staurosporine · in 1 record
Elsewhere
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