MolNFT v1 · #117457 · protein

TGF-beta receptor type 1 kinase domain (wt)

5E8S · TGF-beta receptor type-1: “TGF-beta receptor type 1 kinase domain (wt)”. X-ray diffraction, 3 pockets (best druggability 0.74). MolNFT v1 #117457 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5E8S
Type: protein
Length: 301 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TGF-beta receptor type-1
EC: 2.7.11.30
UniProt: P36897
Pockets: 3 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TGF-beta receptor type-1 (EC 2.7.11.30)	protein	301	40% helix, 21% strand	P36897

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.74	0.98	20	empty
2	303	0.67	0.82	38	empty
3	50	0.29	0.76	11	empty

Compared structures

5E8S · TGF-beta receptor type 1 kinase domain (wt) · the same entry in another collection · chain A against A, TM-score 1.00
P36897 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-1 (P36897) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P36897
Elsewhere: RCSB PDB 5E8S · PDBe 5E8S · UniProt P36897

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.