UniProt P37173
TGF-beta receptor type-2 (P37173)
TGF-beta receptor type-2 (UniProt P37173), EC 2.7.11.30: 31 experimental structures on GenesisL1, 7 ligands bound, 9 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P37173
- Protein
- TGF-beta receptor type-2
- EC
- 2.7.11.30
- Experimental structures
- 31
- Predicted models
- 0
- Ligands
- 7
- Pockets
- 9 · 2 records with a druggable one
Structures
31 records of P37173 in the MolNFT archive: 31 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1KTZ | Crystal Structure of the Human TGF-beta Type II Receptor Extracellular Domain in Complex with… | x-ray diffraction | B | — | — |
| 1KTZ | Crystal structure of the human TGF-beta type II receptor extracellular domain in complex with… | x-ray diffraction | B | — | — |
| 1M9Z | Crystal structure of human TGF-beta type II receptor ligand binding domain | x-ray diffraction | A | — | — |
| 1M9Z | Crystal structure of human TGF-beta type II receptor ligand binding domain | x-ray diffraction | A | — | — |
| 1PLO | Transforming growth factor-beta type II receptor extracellular domain | solution nmr | A | — | — |
| 1PLO | Transforming growth factor-beta type II receptor extracellular domain | solution nmr | A | — | — |
| 2PJY | Structural basis for cooperative assembly of the TGF-beta signaling complex | x-ray diffraction | B | — | — |
| 2PJY | Structural basis for cooperative assembly of the TGF-beta signaling complex | x-ray diffraction | B | — | — |
| 3KFD | Ternary complex of TGF-b1 reveals isoform-specific ligand recognition and receptor recruitment in… | x-ray diffraction | E, F, G, H | — | — |
| 3KFD | Ternary complex of TGF-B1 reveals isoform-specific ligand recognition and receptor recruitment in… | x-ray diffraction | E, F, G, H | — | — |
| 4P7U | Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with NDSB-201 | x-ray diffraction | A | — | — |
| 4P7U | Extracellular domain of type II transforming growth factor beta receptor in complex with ndsb-201 | x-ray diffraction | A | — | — |
| 4XJJ | Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with… | x-ray diffraction | A | — | — |
| 4XJJ | Extracellular domain of type II transforming growth factor beta receptor in complex with… | x-ray diffraction | A | — | — |
| 5E8V | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A,R495A) | x-ray diffraction | A | — | 3 (best 0.66) |
| 5E8V | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A) | x-ray diffraction | A | — | — |
| 5E8Y | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A,R495A) in complex with… | x-ray diffraction | A | STU | 4 (best 0.67) |
| 5E8Y | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A) in complex with… | x-ray diffraction | A | — | — |
| 5E91 | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A,R495A) in complex with… | x-ray diffraction | A | 5L4 | — |
| 5E91 | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A) in complex with… | x-ray diffraction | A | — | — |
| 5E92 | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A,R495A) in complex with amppnp | x-ray diffraction | A | ANP, MG | — |
| 5E92 | TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A) in complex with amppnp | x-ray diffraction | A | — | — |
| 5QIN | TGF-beta receptor type 2 kinase domain in complex with N- {4-[3-(6… | x-ray diffraction | A | J2V | — |
| 5TX4 | Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S… | x-ray diffraction | A | — | — |
| 5TX4 | Derivative of mouse TGF-BETA2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S… | x-ray diffraction | A | — | — |
| 5TY4 | MicroED structure of a complex between monomeric TGF-b and its receptor, TbRII, at 2.9 A resolution | electron crystallography | A | — | — |
| 5TY4 | Microed structure of a complex between monomeric TGF-B and its receptor, tbrii, at 2.9 a resolution | electron crystallography | A | — | — |
| 7DV6 | Discovery of functionally selective transforming growth factor beta type II receptor (TGF-beta rii)… | x-ray diffraction | A | HJF | — |
| 8G4K | Complex of TbRII mini protein binder bound to the TbRII ECD | x-ray diffraction | B | SO4 | 2 (best 0.36) |
| 8GDT | Heligmosomoides polygyrus TGF-beta Mimic 6 Domain 3 (TGM6-D3) Bound to Human TGF-beta Type II… | x-ray diffraction | A | — | — |
| P37173 | AlphaFold monomer V2.0 prediction for TGF-beta receptor type-2 (P37173) | — | — | — |
Ligands
- 5L4 · 3-amino-6-[4-(2-hydroxyethyl)phenyl]-N-[4-(morpholin-4-yl)pyridin-3-yl]pyrazine-2-carboxamide · in 1 record
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 1 record
- HJF · 5-[(3S)-5,5-dimethyloxolan-3-yl]-6-methoxy-3-(2-methoxypyridin-4-yl)pyrazolo[1,5-a]pyrimidine · in 1 record
- J2V · N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide · in 1 record
- MG · Magnesium ion · in 1 record
- SO4 · Sulfate ion · in 1 record
- STU · Staurosporine · in 1 record
Elsewhere
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