MolNFT v1 · #135370 · protein
Derivative of mouse TGF-BETA2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V, I92V, K94R T95K, I98V single amino acid substitutions, bound to human TGF-beta type II receptor ectodomain residues 15-130
5TX4 · TGF-beta receptor type-2: “Derivative of mouse TGF-BETA2, with a deletion of residues 52-71 and K25R, R26K, L51R, A74K, C77S, L89V…”. X-ray diffraction. MolNFT v1 #135370 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TX4
- Type
- protein
- Length
- 199 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TGF-beta receptor type-2; Transforming growth factor beta-2
- EC
- 2.7.11.30
- UniProt
- P37173, P61812
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TGF-beta receptor type-2 (EC 2.7.11.30) | protein | 107 | 3% helix, 46% strand | P37173 |
| B | Transforming growth factor beta-2 | protein | 92 | 12% helix, 54% strand | P61812 |
Interfaces
1 interface between chains.
- A–B · 516 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 5TX4 · Derivative of mouse TGF-beta2, with a deletion of residues 52-71 and K25R, R26K, L51R… · the same entry in another collection · chain A against A, TM-score 1.00
- P37173 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-2 (P37173) · a predicted model of the same protein · chain A against A, TM-score 0.95
- P61812 · AlphaFold monomer V2.0 prediction for transforming growth factor beta-2 proprotein… · a predicted model of the same protein · chain B against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37173
- Every structure of UniProt P61812
- Elsewhere: RCSB PDB 5TX4 · PDBe 5TX4 · UniProt P37173 · UniProt P61812
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