MolNFT v1 · #117460 · protein

TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A)

5E8V · TGF-beta receptor type-2: “TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A, R495A)”. X-ray diffraction, 3 pockets (best druggability 0.66). MolNFT v1 #117460 on GenesisL1: 3D structure, binding sites and…

PDB: 5E8V
Type: protein
Length: 296 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TGF-beta receptor type-2
EC: 2.7.11.30
UniProt: P37173
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TGF-beta receptor type-2 (EC 2.7.11.30)	protein	296	40% helix, 19% strand	P37173

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	292	0.66	0.81	40	empty
2	132	0.60	0.85	27	empty
3	80	0.35	0.75	23	empty

Compared structures

5E8V · TGF-beta receptor type 2 kinase domain (E431A,R433A,E485A,K488A,R493A,R495A) · the same entry in another collection · chain A against A, TM-score 1.00
P37173 · AlphaFold monomer V2.0 prediction for TGF-beta receptor type-2 (P37173) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P37173
Elsewhere: RCSB PDB 5E8V · PDBe 5E8V · UniProt P37173

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