Research workbench
Crystal structure of fis bound to 27BP non consensus sequence DNA F6
Analyse Crystal structure of fis bound to 27BP non consensus sequence DNA F6 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3JRA
- Type
- protein + DNA
- Length
- 243 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA-binding protein fis; DNA (27-mer)
- UniProt
- P0A6R3
- Pockets
- 3 · best druggability 0.62
Structure
x-ray diffraction · 4 distinct chains · 59% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-binding protein fis | protein | 91 | 59% helix, 11% strand | P0A6R3 |
| B | DNA-binding protein fis | protein | 98 | 59% helix, 10% strand | P0A6R3 |
| C | DNA (27-mer) | dna | 27 | — | — |
| D | DNA (27-mer) | dna | 27 | — | — |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 444 | 0.62 | 0.76 | 36 | empty |
| 2 | 154 | 0.44 | 0.75 | 23 | empty |
| 3 | 140 | 0.41 | 0.75 | 23 | empty |
Interfaces
6 interfaces between chains.
- A–B · 2314 Ų buried · 31 hydrogen bonds · protein-protein
- C–D · 1167 Ų buried · 125 hydrogen bonds · nucleic-nucleic
- A–D · 281 Ų buried · 11 hydrogen bonds · protein-nucleic
- B–C · 269 Ų buried · 15 hydrogen bonds · protein-nucleic
- A–C · 253 Ų buried · 5 hydrogen bonds · protein-nucleic
Compared structures
- 3JRA · Crystal structure of Fis bound to 27bp non consensus sequence DNA F6 · the same entry in another collection · chain A against A, TM-score 1.00
- P0A6R3 · AlphaFold monomer V2.0 prediction for DNA-binding protein fis (P0A6R3) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A6R3
- Elsewhere: RCSB PDB 3JRA · PDBe 3JRA · UniProt P0A6R3
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