Research workbench
Kinesin-13 KLP10A hd in complex with cs-tubulin and a microtubule
Analyse Kinesin-13 KLP10A hd in complex with cs-tubulin and a microtubule in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3J2U
- Type
- protein
- Length
- 1,985 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kinesin-like protein KLP10A; Tubulin alpha-1A chain; Tubulin beta-2B chain
- UniProt
- Q960Z0, P81947, Q6B856
- Pockets
- 20 · best druggability 0.83
Structure
electron microscopy · 3 distinct chains · 41% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| K | Kinesin-like protein KLP10A | protein | 309 | 33% helix, 30% strand | Q960Z0 |
| A, C | Tubulin alpha-1A chain | protein | 412 | 44% helix, 14% strand | P81947 |
| B, D | Tubulin beta-2B chain | protein | 426 | 44% helix, 14% strand | Q6B856 |
Pockets
20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 263 | 0.83 | 0.95 | 44 | empty |
| 2 | 855 | 0.78 | 0.81 | 82 | empty |
| 3 | 69 | 0.72 | 0.96 | 27 | empty |
| 4 | 266 | 0.69 | 0.84 | 37 | empty |
| 5 | 654 | 0.66 | 0.76 | 74 | empty |
Interfaces
5 interfaces between chains.
- C–D · 1406 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 346 Ų buried · 6 hydrogen bonds · protein-protein
- K–B · 306 Ų buried · 5 hydrogen bonds · protein-protein
- K–D · 161 Ų buried · 0 hydrogen bonds · protein-protein
- K–A · 89 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 3J2U · Kinesin-13 KLP10A HD in complex with CS-tubulin and a microtubule · the same entry in another collection · chain K against K, TM-score 1.00
- Q960Z0 · AlphaFold monomer V2.0 prediction for kinesin-like protein KLP10A (Q960Z0) · a predicted model of the same protein · chain K against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q960Z0
- Every structure of UniProt P81947
- Every structure of UniProt Q6B856
- Elsewhere: RCSB PDB 3J2U · PDBe 3J2U · UniProt Q960Z0 · UniProt P81947 · UniProt Q6B856
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