Structures of spop-substrate complexes: insights into architectures of btb-CUL3 ubiquitin ligases: spopmath- MACROH2ASBCPEP1

Structure

x-ray diffraction · 2 distinct chains · 12% helix, 43% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 5 copies · chains A
• CL · Chloride ion · ion · chains A, M

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–M · 553 Ų buried · 17 hydrogen bonds · protein-protein

Compared structures

• 3IVB · Structures of SPOP-Substrate Complexes: Insights into Architectures of BTB-Cul3 Ubiquitin… · the same entry in another collection · chain A against A, TM-score 1.00
• O43791 · AlphaFold monomer V2.0 prediction for speckle-type poz protein (O43791) · a predicted model of the same protein · chain A against A, TM-score 0.93
• O75367 · AlphaFold monomer V2.0 prediction for core histone macro-H2A.1 (O75367) · a predicted model of the same protein · chain M against A, TM-score 0.24

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt O43791
• Every structure of UniProt O75367
• Elsewhere: RCSB PDB 3IVB · PDBe 3IVB · UniProt O43791 · UniProt O75367