Research workbench
Interferon-lambda is functionally an interferon but structurally related to the il-10 family
Analyse Interferon-lambda is functionally an interferon but structurally related to the… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3HHC
- Type
- protein
- Length
- 559 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-28B
- UniProt
- Q8IZI9
- Ligands
- IOD
- Pockets
- 8 · best druggability 0.70
Structure
x-ray diffraction · 4 distinct chains · 67% helix, 1% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-28B | protein | 153 | 73% helix, 1% strand | Q8IZI9 |
| B | Interleukin-28B | protein | 157 | 68% helix, 1% strand | Q8IZI9 |
| C | Interleukin-28B | protein | 151 | 69% helix, 1% strand | Q8IZI9 |
| D | Interleukin-28B | protein | 98 | 54% helix, 1% strand | Q8IZI9 |
Ligands and binding sites
- IOD · Iodide ion · ion · 35 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
8 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 596 | 0.70 | 0.78 | 60 | IOD |
| 2 | 216 | 0.61 | 0.81 | 21 | IOD |
| 3 | 189 | 0.61 | 0.82 | 26 | IOD |
| 4 | 56 | 0.60 | 0.91 | 16 | empty |
| 5 | 178 | 0.56 | 0.80 | 27 | IOD |
Interfaces
5 interfaces between chains.
- B–D · 1177 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 1126 Ų buried · 11 hydrogen bonds · protein-protein
- B–C · 329 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 322 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 293 Ų buried · 3 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 11 disulfide (disulfide).
Compared structures
- 3HHC · Interferon-lambda is functionally an interferon but structurally related to the IL-10… · the same entry in another collection · chain D against D, TM-score 1.00
- Q8IZI9 · AlphaFold monomer V2.0 prediction for interferon lambda-3 (Q8IZI9) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IZI9
- Elsewhere: RCSB PDB 3HHC · PDBe 3HHC · UniProt Q8IZI9
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.