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Prtc methionine mutants: M226H desy

Analyse Prtc methionine mutants: M226H desy in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB
3HBU
Type
protein
Length
466 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Secreted protease C; Peptide
EC
3.4.24.-
UniProt
P16317
Ligands
CA, ZN, CL
Pockets
4 · best druggability 0.54

Structure

x-ray diffraction · 2 distinct chains · 19% helix, 25% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
PSecreted protease C (EC 3.4.24.-)protein46219% helix, 24% strandP16317
ZPeptideprotein40% helix, 50% strand—

Ligands and binding sites

  • CA · Calcium ion · metal · 7 copies · chains P
  • ZN · Zinc ion · metal · 3 copies · chains P, Z
  • CL · Chloride ion · ion · 2 copies · chains P

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11280.540.8221ZN
2560.480.8519empty
31100.370.7423empty
4670.310.7515empty

Interfaces

1 interface between chains.

  • P–Z · 367 Ų buried · 9 hydrogen bonds · protein-protein

Compared structures

  • 3HBU · PrtC methionine mutants: M226H DESY · the same entry in another collection · chain P against P, TM-score 1.00
  • P16317 · AlphaFold monomer V2.0 prediction for serralysin C (P16317) · a predicted model of the same protein · chain P against A, TM-score 1.00

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