Research workbench
Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain
Analyse Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 3H2X
- Type
- protein
- Length
- 302 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein phosphatase non-receptor type 22
- EC
- 3.1.3.48
- UniProt
- Q9Y2R2
- Ligands
- PO4
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 22 (EC 3.1.3.48) | protein | 302 | 38% helix, 17% strand | Q9Y2R2 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 5 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 189 | 0.53 | 0.78 | 29 | PO4 |
| 2 | 138 | 0.46 | 0.77 | 23 | empty |
| 3 | 91 | 0.35 | 0.74 | 14 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 3H2X · Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q9Y2R2 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 22… · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y2R2
- Elsewhere: RCSB PDB 3H2X · PDBe 3H2X · UniProt Q9Y2R2
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