MolNFT v1 · #319639 · protein
AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 22 (Q9Y2R2)
Q9Y2R2: “AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 22 (Q9Y2R2)”. 6 pockets (best druggability 0.64). MolNFT v1 #319639 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- Q9Y2R2
- Type
- protein
- Length
- 807 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0xB6F9E42B42dBC2b9Bd69c9f21BD545B46139e3d6
- Molecule
- Tyrosine-protein phosphatase non-receptor type 22
- UniProt
- Q9Y2R2
- Pockets
- 6 · best druggability 0.64
Structure
1 distinct chain · 16% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein phosphatase non-receptor type 22 | protein | 807 | 16% helix, 7% strand | Q9Y2R2 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 395 | 0.64 | 0.78 | 43 | empty |
| 2 | 291 | 0.62 | 0.79 | 37 | empty |
| 3 | 83 | 0.39 | 0.77 | 14 | empty |
| 4 | 116 | 0.36 | 0.73 | 18 | empty |
| 5 | 50 | 0.33 | 0.78 | 9 | empty |
Compared structures
- 3H2X · Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 3H2X · Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 4J51 · Cyrstal structure of protein tyrosine phosphatase lyp catalytic domain complex with small… · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 4J51 · Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small… · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 2P6X · Crystal structure of human tyrosine phosphatase PTPN22 · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 2P6X · Crystal structure of human tyrosine phosphatase PTPN22 · an experimental structure of the same protein · chain A against A, TM-score 0.37
- 3BRH · Protein tyrosine phosphatase ptpn-22 (lyp) bound to the mono- phosphorylated lck active… · an experimental structure of the same protein · chain A against B, TM-score 0.37
- 3BRH · Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active… · an experimental structure of the same protein · chain A against B, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Y2R2
- Elsewhere: UniProt Q9Y2R2 · AlphaFold DB Q9Y2R2
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