UniProt Q9Y2R2
Tyrosine-protein phosphatase non-receptor type 22 (Q9Y2R2)
Tyrosine-protein phosphatase non-receptor type 22 (UniProt Q9Y2R2), EC 3.1.3.48: 18 experimental structures and 1 predicted model on GenesisL1, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- Q9Y2R2
- Protein
- Tyrosine-protein phosphatase non-receptor type 22
- EC
- 3.1.3.48
- Experimental structures
- 18
- Predicted models
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
19 records of Q9Y2R2 in the MolNFT archive: 18 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2P6X | Crystal structure of human tyrosine phosphatase PTPN22 | x-ray diffraction | A, B | — | — |
| 2P6X | Crystal structure of human tyrosine phosphatase PTPN22 | x-ray diffraction | A, B | — | — |
| 2QCJ | Native Structure of Lyp | x-ray diffraction | A, B | — | — |
| 2QCJ | Native structure of lyp | x-ray diffraction | A, B | — | — |
| 2QCT | Structure of Lyp with inhibitor I-C11 | x-ray diffraction | A, B | — | — |
| 2QCT | Structure of lyp with inhibitor I-C11 | x-ray diffraction | A, B | — | — |
| 3BRH | Protein Tyrosine Phosphatase PTPN-22 (Lyp) bound to the mono-Phosphorylated Lck active site peptide | x-ray diffraction | A, B | — | — |
| 3BRH | Protein tyrosine phosphatase ptpn-22 (lyp) bound to the mono- phosphorylated lck active site peptide | x-ray diffraction | A, B | — | — |
| 3H2X | Crystal Structure of The Human Lymphoid Tyrosine Phosphatase Catalytic Domain | x-ray diffraction | A | — | — |
| 3H2X | Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain | x-ray diffraction | A | — | — |
| 3OLR | PTPN22 in complex with consensus phospho-tyrosine peptide 1 | x-ray diffraction | A, B, C, D | — | — |
| 3OLR | PTPN22 in complex with consensus phospho-tyrosine peptide 1 | x-ray diffraction | A, B, C, D | — | — |
| 3OMH | Crystal structure of PTPN22 in complex with SKAP-HOM pTyr75 peptide | x-ray diffraction | A, B, C, D | — | — |
| 3OMH | Crystal structure of PTPN22 in complex with skap-hom PTYR75 peptide | x-ray diffraction | A, B, C, D | — | — |
| 4J51 | Cyrstal structure of protein tyrosine phosphatase Lyp catalytic domain complex with small molecular… | x-ray diffraction | A, B | — | — |
| 4J51 | Cyrstal structure of protein tyrosine phosphatase lyp catalytic domain complex with small molecular… | x-ray diffraction | A, B | — | — |
| 7AAM | Crystal structure of the F-BAR domain of PSTIPIP1 bound to the CTH domain of the phosphatase LYP | x-ray diffraction | C | — | — |
| 7AAM | Crystal structure of the F-bar domain of PSTIPIP1 bound to the cth domain of the phosphatase lyp | x-ray diffraction | C | — | — |
| Q9Y2R2 | AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase non-receptor type 22 (Q9Y2R2) | predicted | A | — | 6 (best 0.64) |
Experiment against prediction
- 3BRH chain B against the predicted model Q9Y2R2: TM-score 0.99, RMSD 0.67 Å
- 3BRH chain B against the predicted model Q9Y2R2: TM-score 0.99, RMSD 0.67 Å
- 3BRH chain A against the predicted model Q9Y2R2: TM-score 0.99, RMSD 0.64 Å
- 3BRH chain A against the predicted model Q9Y2R2: TM-score 0.99, RMSD 0.64 Å
- 2P6X chain B against the predicted model Q9Y2R2: TM-score 0.98, RMSD 1.06 Å
- 2P6X chain B against the predicted model Q9Y2R2: TM-score 0.98, RMSD 1.06 Å
- 3OMH chain B against the predicted model Q9Y2R2: TM-score 0.97, RMSD 1.29 Å
- 3OMH chain B against the predicted model Q9Y2R2: TM-score 0.97, RMSD 1.29 Å
- 4J51 chain A against the predicted model Q9Y2R2: TM-score 0.97, RMSD 1.23 Å
- 4J51 chain A against the predicted model Q9Y2R2: TM-score 0.97, RMSD 1.23 Å
Elsewhere
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