Research workbench

Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924

Analyse Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 3GZN
Type: protein
Length: 2,069 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q13564, Q8TBC4, Q15843

Structure

x-ray diffraction · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	527	—	Q13564
B, D	—	protein	429	—	Q8TBC4
C	—	protein	526	—	Q13564
I, J	—	protein	79	—	Q15843

Compared structures

3GZN · Structure of NEDD8-activating enzyme in complex with NEDD8 and MLN4924 · the same entry in another collection · chain J against J, TM-score 1.00
Q8TBC4 · AlphaFold monomer V2.0 prediction for NEDD8-activating enzyme E1 catalytic subunit… · a predicted model of the same protein · chain B against A, TM-score 0.99
Q13564 · AlphaFold monomer V2.0 prediction for NEDD8-activating enzyme E1 regulatory subunit… · a predicted model of the same protein · chain C against A, TM-score 0.99
Q15843 · AlphaFold monomer V2.0 prediction for NEDD8 (Q15843) · a predicted model of the same protein · chain I against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13564
Every structure of UniProt Q8TBC4
Every structure of UniProt Q15843
Elsewhere: RCSB PDB 3GZN · PDBe 3GZN · UniProt Q13564 · UniProt Q8TBC4 · UniProt Q15843

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